Evidence map›Paper›PMID 41219060›Full record

SynthesisJournal of epidemiology and community health2026

Impact of parental adverse childhood experiences on children's healthcare utilisation: a systematic review.

Mark F M Ketelaars, Merel Sprenger, Anouk J M Bos, Anne M de Grauw, Michiel Burger, Mirjam van Veen, Jessica C Kiefte-de Jong

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of epidemiology and community health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mark F M KetelaarsDepartment of Public Health and Primary Care/Health Campus The Hague, Leiden University Medical Center, Leiden, South-Holland, Netherlands m.f.m.ketelaars@lumc.nl.ORCID http://orcid.org/0000-0001-5602-7294
Merel SprengerDepartment of Public Health and Primary Care/Health Campus The Hague, Leiden University Medical Center, Leiden, South-Holland, Netherlands.
Anouk J M BosHaga Hospital Juliana Children's Hospital, The Hague, South Holland, Netherlands.
Anne M de GrauwHaga Hospital Juliana Children's Hospital, The Hague, South Holland, Netherlands.
Michiel BurgerHaga Hospital Juliana Children's Hospital, The Hague, South Holland, Netherlands.
Mirjam van VeenHaga Hospital Juliana Children's Hospital, The Hague, South Holland, Netherlands.
Jessica C Kiefte-de JongDepartment of Public Health and Primary Care/Health Campus The Hague, Leiden University Medical Center, Leiden, South-Holland, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdverse childhood experiences (ACEs) are linked to poor health and social outcomes, with growing interest in their intergenerational effects. Socioeconomic context strongly shapes both exposure to ACEs and their transmission across generations, yet is often under-represented in research. While many studies have explored how ACEs affect adult health, the impact of parental ACEs on children's healthcare utilisation has not yet been systematically reviewed.

methodsWe systematically reviewed studies examining associations between parental ACEs or related adversity and children's use of preventive, primary or secondary healthcare. We searched PubMed, Embase and PsycINFO databases up to December 2024. Title and abstract screening were conducted using an AI-assisted screening tool called Active Learning for Systematic Reviews. Study quality was assessed across design, participant selection, measurement and analysis. Findings were synthesised narratively and visualised with harvest plots, grouped by healthcare level and exposure type.

resultsOut of 8494 records, 15 studies were included. Designs, populations, ACE measures and outcome definitions were heterogeneous. No consistent associations were found in preventive or primary care domains. In secondary care, 11 of 12 analyses found a positive or no association; four high-quality studies showed increased use of emergency, inpatient or psychiatric services among children of parents with ACEs. Methodological variability limited comparability between studies, particularly in ACE definitions.

conclusionsParental ACEs may contribute to increased use of secondary healthcare in offspring, though evidence across care levels remains inconclusive. Future studies should aim for more consistent measurement of ACEs and standardised outcome definitions to clarify intergenerational effects on healthcare utilisation.

Indexed as

Adverse Childhood ExperiencesParentsPatient Acceptance of Health CareChildHumansCHILD HEALTHHEALTHCARE DISPARITIESHEALTH SERVICESLife course epidemiologyMENTAL HEALTH

Identifiers

PMID41219060
PMCPMC12911568

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.