ArticleEuropean journal of hospital pharmacy : science and practice2026
NHS Yellow Cover Document integrity performance assessment of two needle-free closed system transfer devices as terminal closure/access for Luer-Lock syringes and IV bags.
Article in European journal of hospital pharmacy : science and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the container closure integrity of needle-free Closed System Transfer Device (CSTD) components (ChemoClave and ChemoLock) combined with Luer-Lock (LL) syringes and IV bags as a terminal closure/access device. The UK NHS Yellow Cover Document (YCD) requires containment data for final storage devices of aseptic chemotherapy drugs when prepared in advance in pharmaceutical technical services (PTS). Assessment of both physical and microbial integrity of all combinations was performed: syringe adapter/LL syringes and vented bag adaptor/IV bags. All container combinations were subject to an additional vibrational challenge, with three-axis vibrational data logging representing a typical transportation excursion.
methodsContainer integrity testing was performed according to YCD requirements "Protocols for the Integrity Testing of Syringes" for ChemoClave and ChemoLock syringe adapters (CH2000S/CL2000S) and for ChemoClave and ChemoLock vented bag spikes (CH-14/CL-14) as terminal closure devices. Microbiological integrity was assessed according to Method 1, Part 1.4 using
resultsChemoClave and ChemoLock syringe adapters and vented bag spikes/IV bags were shown to be free of microbiological contamination (n=160) and free of dye intrusion (n=80 in total). The data support both ChemoClave and ChemoLock CSTD components as closure for aseptic preparations of pharmaceutical drug products in PTS. 100% closure integrity was demonstrated.
conclusionsChemoClave and ChemoLock CSTD components showed 100% container integrity in accordance with YCD requirements as terminal closure for LL syringes and IV bags in PTS. ChemoClave and ChemoLock syringe adapters and vented bag spike components can be used for the preparation of chemotherapeutic drug products prepared in advance in UK PTS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.