Evidence map›Paper›PMID 41218815›Full record

ArticleBrain tumor research and treatment2025

Postoperative Seizures Can Predict Overall Survival of Patients With Newly Diagnosed Supratentorial Isocitrate Dehydrogenase-Wild Glioblastoma Treated With Radiotherapy Plus Concomitant and Adjuvant Temozolomide.

Kengo Yamada, Ryosuke Matsuda, Ryota Sasaki, Ryosuke Maeoka, Tsutomu Nakazawa, Takayuki Morimoto, Yudai Morisaki, Shohei Yokoyama, Masashi Kotsugi, Yasuhiro Takeshima and 4 more

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Article in Brain tumor research and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Kengo YamadaDepartment of Neurosurgery, Nara Medical University, Kashihara, Japan.ORCID https://orcid.org/0009-0007-2196-6559
Ryosuke MatsudaDepartment of Neurosurgery, Nara Medical University, Kashihara, Japan. rmatsudap@naramed-u.ac.jp.ORCID https://orcid.org/0000-0002-0307-3657
Ryota SasakiDepartment of Neurosurgery, Nara Medical University, Kashihara, Japan.ORCID https://orcid.org/0000-0003-4316-4139
Ryosuke MaeokaDepartment of Neurosurgery, Nara Medical University, Kashihara, Japan.ORCID https://orcid.org/0000-0003-1441-838X
Tsutomu NakazawaDepartment of Neurosurgery, Nara Medical University, Kashihara, Japan.ORCID https://orcid.org/0000-0003-4286-9356
Takayuki MorimotoDepartment of Neurosurgery, Nara Medical University, Kashihara, Japan.ORCID https://orcid.org/0000-0002-9974-3538
Yudai MorisakiDepartment of Neurosurgery, Nara Medical University, Kashihara, Japan.ORCID https://orcid.org/0000-0002-6348-2372
Shohei YokoyamaDepartment of Neurosurgery, Nara Medical University, Kashihara, Japan.ORCID https://orcid.org/0000-0002-1849-4200
Masashi KotsugiDepartment of Neurosurgery, Nara Medical University, Kashihara, Japan.ORCID https://orcid.org/0000-0002-3964-7261
Yasuhiro TakeshimaDepartment of Neurosurgery, Nara Medical University, Kashihara, Japan.ORCID https://orcid.org/0000-0002-5438-6098
Shuichi YamadaDepartment of Neurosurgery, Nara Medical University, Kashihara, Japan.ORCID https://orcid.org/0000-0002-7278-3978
Fumihiko NishimuraDepartment of Neurosurgery, Nara Medical University, Kashihara, Japan.ORCID https://orcid.org/0000-0002-9962-7852
Young-Soo ParkDepartment of Neurosurgery, Nara Medical University, Kashihara, Japan.ORCID https://orcid.org/0000-0003-2271-1332
Ichiro NakagawaDepartment of Neurosurgery, Nara Medical University, Kashihara, Japan.ORCID https://orcid.org/0000-0002-1340-3293

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to evaluate the correlation between postoperative seizures (POS) and overall survival in patients with newly diagnosed supratentorial isocitrate dehydrogenase (IDH)-wild glioblastoma treated with radiotherapy plus concomitant and adjuvant temozolomide.

methodsThis study included 122 patients with newly diagnosed supratentorial IDH-wild glioblastoma who were treated at our hospital between May 2007 and September 2022. Seizures occurring within 7 days after surgery were defined as immediate POS (iPOS). Moreover, seizures from the 8th day after the surgery were defined as delayed POS (dPOS).

resultsThe median follow-up period and median survival time (MST) from surgery in the entire cohort were 19.3 and 20.4 months, respectively. The rates of iPOS and dPOS in this study were 6.6% (n=8) and 38.5% (n=47), respectively. The MST of patients with iPOS and without iPOS was 27.6 and 20 months, respectively. There was no significant difference between with iPOS and without iPOS. The median time to onset of dPOS was 126 days after surgery. The MST of patients with dPOS and without dPOS was 25.9 and 18.4 months, respectively. Patients with dPOS showed significantly longer survival than those without dPOS (

conclusionAmong patients with newly diagnosed supratentorial IDH-wild glioblastoma, the prognosis of patients with seizures in the postoperative course was better than that of patients without dPOS.

Indexed as

GlioblastomaIsocitrate dehydrogenasePostoperative seizurePreoperative seizurePrognostic factors

Identifiers

PMID41218815
PMCPMC12621835

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