Evidence map›Paper›PMID 41218813›Full record

ReviewBrain tumor research and treatment2025

Sonodynamic Therapy With Orally Absorbable Nanomedicine for Brain Tumor.

Chaerim Yoo, Jihyeon Kim, Dong Yun Lee

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain tumor research and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chaerim YooDepartment of Bioengineering, College of Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0009-0008-3206-6289
Jihyeon KimDepartment of Bioengineering, College of Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0009-0001-6628-7839
Dong Yun LeeDepartment of Bioengineering, College of Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0000-0001-7691-0447

Funding

Korean Fund for Regenerative Medicine KFRM24A0105L1Korean Fund for Regenerative Medicine KFRM25A0107L1Ministry of SMEs and Startups of Korea RS-2023-00282845
6 · The paper itself

Abstract

Glioblastoma (GBM) is an aggressive and treatment-resistant brain tumor with poor prognosis despite surgery, radiotherapy, and chemotherapy. Sonodynamic therapy (SDT), which combines low-intensity focused ultrasound with systemically or orally administered sonosensitizers, has emerged as a promising non-invasive approach to achieve localized tumor cell killing via reactive oxygen species. Recent advances in nanomedicine have enabled the development of orally absorbable, blood-brain barrier permeable delivery systems that enhance tumor targeting and ultrasound responsiveness. Preclinical studies have demonstrated consistent anti-tumor efficacy and immune activation, while early clinical trials suggest SDT is safe, feasible, and potentially effective in recurrent GBM. This review outlines recent progress in SDT-based strategies for GBM, with emphasis on mechanistic insights, delivery innovations, and clinical translation.

Indexed as

Blood–brain barrierFocused ultrasoundGlioblastomaOrally absorbable nanomedicineSonodynamic therapy

Identifiers

PMID41218813
PMCPMC12621860

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.