Evidence map›Paper›PMID 41218783›Full record

ArticleProceedings. Biological sciences2025

Heterogeneous constraint and adaptation across the malaria parasite life cycle.

Sarah A Perkins, Daniel E Neafsey, Angela M Early

Abstract read
In one paragraph

Article in Proceedings. Biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Rare variation in malaria parasites biases population-genetic inference.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Sarah A PerkinsDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-0557-3102
Daniel E NeafseyDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-1665-9323
Angela M EarlyInfectious Disease and Microbiome Program, Broad Institute, Cambridge, MA, USA.ORCID 0000-0002-3169-2324

Funding

The Graduate Program in Tropical Infectious Diseases (GPiTID)T32AI049928 · NIAID · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Flaminia Catteruccia, Phyllis J. Kanki · 2001 to 2026
$5.0M
National Institute of Allergy and Infectious DiseasesNIAID NIH HHS T32 AI049928
6 · The paper itself

Abstract

Evolutionary forces vary across genomes, creating disparities in how traits evolve. In organisms with complex life cycles, it is unclear how intrinsic differences among discrete life stages impact evolution. Here, we look for life history-driven patterns of adaptation in

Indexed as

Adaptation, PhysiologicalGenetic HeterogeneityLife Cycle StagesMalaria, FalciparumPlasmodium falciparumAnimalsAntimalarialsGene Expression Regulation, DevelopmentalGenes, ProtozoanHumansLife History TraitsMosquito VectorsSingle-Cell Gene Expression AnalysisTime FactorsAntimalarialsadaptationcomplex life cyclemalariaPlasmodiumselection efficacy

Identifiers

PMID41218783
PMCPMC12606260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.