ArticleThe Journal of pharmacology and experimental therapeutics2025
Factors that influence the conditioned reinforcing effects of a cocaine-associated stimulus.
Article in The Journal of pharmacology and experimental therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cocaine-associated stimuli acquire conditioned reinforcing effects and can precipitate relapse. We used the New Response Acquisition procedure to examine factors that influenced the conditioned reinforcing effects of cocaine-associated stimuli in rats. According to this procedure, rats first experienced Pavlovian conditioning, during which they were exposed to intravenous cocaine deliveries and stimulus (light + white noise) presentations. After Pavlovian conditioning, animals learned to respond to the cocaine-paired stimulus alone. The number of responses made for that stimulus reflected the conditioned reinforcing effects of the cocaine-associated stimulus. Across 3 experiments, the extent to which the dose of cocaine during Pavlovian conditioning (experiment 1), food restriction (experiment 2), and the number of cocaine-stimulus pairings and the number of days of Pavlovian conditioning (experiment 3) led to different conditioned reinforcing effects of the cocaine-associated stimulus. Taken together, we found that cocaine-associated cues took on conditioned reinforcing effects dose-dependently, were augmented by food restriction, and were most robust following 10 days of Pavlovian conditioning relative to 5 days of conditioning. These findings advance our understanding of the conditions under which cocaine-associated stimuli can act as a conditioned reinforcer. SIGNIFICANCE STATEMENT: Cocaine-associated stimuli acquire conditioned reinforcing effects via Pavlovian conditioning that drive drug-seeking and relapse. Understanding the conditions under which cocaine-associated stimuli take on conditioned reinforcing effects can be used to inform efforts to curtail cocaine use disorder.
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