Evidence map›Paper›PMID 41218122›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Sirt6 prevents the age-related decline of H

Noga Touitou, Liat Nahum, Sarit Feldman-Trabelsi, Matan Y Avivi, Miguel A Aon, Shoshana Naiman, Moran Rathaus, Asaf A Gertler, Asael Roichman, Lia Berkman Dvir and 14 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Noga TouitouThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Liat NahumThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Sarit Feldman-TrabelsiThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Matan Y AviviThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Miguel A AonTranslational Gerontology Branch and Laboratory of Cardiovascular Sciences, National Institute on Aging, NIH, Baltimore, MD, 21224.ORCID 0000-0002-4355-5431
Shoshana NaimanThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Moran RathausThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.ORCID 0009-0001-3265-5285
Asaf A GertlerThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Asael RoichmanThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.ORCID 0000-0001-9538-0103
Lia Berkman DvirThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Michel BernierTranslational Gerontology Branch and Laboratory of Cardiovascular Sciences, National Institute on Aging, NIH, Baltimore, MD, 21224.ORCID 0000-0002-5948-368X
Nirad BanskotaTranslational Gerontology Branch and Laboratory of Cardiovascular Sciences, National Institute on Aging, NIH, Baltimore, MD, 21224.
Lir BeckDepartment of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Ron NagarThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Zacharia SchwartzThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Nathan L PriceTranslational Gerontology Branch and Laboratory of Cardiovascular Sciences, National Institute on Aging, NIH, Baltimore, MD, 21224.
Michal HarelDepartment of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Batia LerrerThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Isao IshiiDepartment of Health Chemistry, Showa Pharmaceutical University, Tokyo 194-8543, Japan.ORCID 0000-0002-5367-205X
Hanoch SenderowitzDepartment of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel.ORCID 0000-0003-0076-1355
Ruin MoaddelTranslational Gerontology Branch and Laboratory of Cardiovascular Sciences, National Institute on Aging, NIH, Baltimore, MD, 21224.
Tamar GeigerDepartment of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Rafael de CaboTranslational Gerontology Branch and Laboratory of Cardiovascular Sciences, National Institute on Aging, NIH, Baltimore, MD, 21224.ORCID 0000-0003-2830-5693
Haim Y CohenThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.ORCID 0000-0002-6613-8710

Funding

Azrieli Foundation (La Fondation Azrieli) 418013Israel Cancer Research Fund (ICRF) 590900Israel Science Foundation (ISF) 890/21Minerva Foundation (Minerva Stiftung) AZ5746940769Ministry of Innovation, Science and Technology (MOST) 3-16595SAGOL Network 205463Samuel Waxman Cancer Research Foundation (SWCRF) 590900United States - Israel Binational Science Foundation (BSF) 2023151
6 · The paper itself

Abstract

Mice overexpressing Sirt6 or fed a caloric restriction (CR) diet live longer with improved health. CR increases Sirt6 levels, and its beneficial effects are mediated by the gasotransmitter H

Indexed as

AgingCarbonHydrogen SulfideSirtuinsAcetylationAnimalsCaloric RestrictionHumansLiverLongevityMaleMiceMice, Inbred C57BLS-AdenosylmethionineCarbonHydrogen SulfideS-AdenosylmethionineSirt6 protein, mouseSirtuinsacetylationagingH2Sone carbon pathwaySIRT6

Identifiers

PMID41218122
PMCPMC12646208

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.