Evidence map›Paper›PMID 41218118›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

FZD7 expression marks mammary tumor-initiating cells.

Christina C N Wu, Naycari De Luna, Erin Hairston, Erin D Jeffs, Ashley Key, Stephen R Adams, Sunil J Advani, Terry Gaasterland, Dennis A Carson, Karl Willert

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christina C N WuDepartment of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0695.
Naycari De LunaDepartment of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0695.
Erin HairstonDepartment of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0695.
Erin D JeffsDepartment of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0695.
Ashley KeyDepartment of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0695.
Stephen R AdamsDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92093.
Sunil J AdvaniDepartment of Radiation Medicine and Applied Science, University of California, San Diego, La Jolla, CA 92093.
Terry GaasterlandMarine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0202.ORCID 0000-0003-4023-9342
Dennis A CarsonDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0001-5273-0804
Karl WillertDepartment of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0695.ORCID 0000-0002-8020-6804

Funding

Exploring Wnt-Fzd signaling specificitiesR35GM134961 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WILLERT, KARL H · 2020 to 2024
$2.3M
Analyzing the role of Wnt signaling in pluripotencyR01GM110304 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WILLERT, KARL H · 2014 to 2019
$1.8M
Incucyte Zoom Live Cell Analysis SystemS10OD025060 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WILLERT, KARL H · 2018 to 2018
$173k
Mary Kay Ash Foundation (MKF) 06-20NIGMS NIH HHS R01 GM110304NIGMS NIH HHS R35 GM134961NIH HHS S10 OD025060
6 · The paper itself

Abstract

The WNT signaling pathway has long been implicated in tumorigenesis across multiple cancer types, including breast cancer. However, the complexity arising from the large number of WNTs and their receptors has made it challenging to pinpoint specific components driving tumor development. Using the MMTV-

Indexed as

Breast NeoplasmsFrizzled ReceptorsMammary Neoplasms, ExperimentalNeoplastic Stem CellsAnimalsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansImmunoconjugatesMiceMice, TransgenicTriple Negative Breast NeoplasmsWnt1 ProteinWnt Signaling PathwayFrizzled ReceptorsFZD7 protein, humanFzd7 protein, mouseImmunoconjugatesWnt1 Proteinantibody drug conjugatebreast cancerFZDtumor organoidsWNT

Identifiers

PMID41218118
PMCPMC12646316

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.