Evidence map›Paper›PMID 41218111›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Mechanomedicine: Present state and future promise.

Ning Wang, Shu Chien, Martin A Schwartz

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ning WangInstitute for Mechanobiology and Department of Bioengineering, College of Engineering, Northeastern University, Boston, MA 02115.ORCID 0000-0001-7531-7385
Shu ChienDepartment of Bioengineering, Institute of Engineering in Medicine, University of California at San Diego, La Jolla, CA 92093.ORCID 0000-0003-0332-285X
Martin A SchwartzDepartments of Internal Medicine (Cardiovascular Medicine), Cell Biology, and Biomedical Engineering, Cardiovascular Research Center, Yale University, New Haven CT 06511.ORCID 0000-0002-2071-1243

Funding

Bioengineering to map stress propagation in cytoskeletonR01GM072744 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Ning Wang · 2005 to 2026
$7.6M
Role of Spatiotemporal Epigenetic Dynamics in Regulating Endothelial Gene Expressions under FlowsR01HL121365 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHIEN, SHU, WANG, YINGXIAO · 2014 to 2025
$7.5M
Flow regulation of the Alk1/Eng pathway in vascular homeostasis and diseaseR01HL169510 · NHLBI · YALE UNIVERSITY · PI Anne Christine Eichmann, Martin A Schwartz · 2023 to 2026
$3.0M
Shear stress Regulation of Endothelial Glycolysis via METTL3-mediated RNA m6A ModificationR01HL170107 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHU CHIEN, John YJ Shyy · 2024 to 2026
$2.5M
A QUANTITATIVE, PREDICTIVE MODEL OF VASCULAR REMODELING IN HEALTH AND DISEASER01HL171773 · NHLBI · YALE UNIVERSITY · PI Martin A Schwartz, Michael Simons · 2024 to 2026
$2.0M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL163365HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM072744HHS | NIH | NHLBI | Division of Intramural Research (DIR) HL169510HHS | NIH | NHLBI | Division of Intramural Research (DIR) HL170107HHS | NIH | NHLBI | Division of Intramural Research (DIR) HL171773NHLBI NIH HHS R01 HL121365NHLBI NIH HHS R01 HL169510NHLBI NIH HHS R01 HL170107NHLBI NIH HHS R01 HL171773NIGMS NIH HHS R01 GM072744
6 · The paper itself

Abstract

Two recent conferences on mechanotransduction in biology and medicine showcased remarkable progress in this field and the potential for bringing mechanobiology into the clinic. In this Perspective, we discuss recent advances, the conceptual frameworks needed to develop clinical tools based on mechanobiology, and prospects for the future.

Indexed as

BiophysicsMechanotransduction, CellularAnimalsHumansmechanobiologymechanodiagnosticsmechanohealthmechanotherapymechanotransduction

Identifiers

PMID41218111
PMCPMC12646207

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.