Trial reportActa physiologica (Oxford, England)2025
Effects of Heat Exposure on Kynurenine Pathway Metabolism-Comparison Between Exertional and Exogenous Heating of the Human Body.
Trial report in Acta physiologica (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Effects of Heat Exposure on Kynurenine Pathway Metabolism-Comparison Between Exertional and Exogenous Heating of the Human Body.Acta physiologica (Oxford, England) · 2025Trial
- Cell-free DNA, cytokine, and catecholamine levels did not differ between sexes under a matched body core temperature increase, despite females exhibiting a more rapid increase in rectal temperature.European journal of applied physiology · 2026Article
- Prenatal exposure to heat stress and postpartum depressive symptoms in the MADRES cohort in urban Los Angeles.Environmental research · 2026Article
- The kynurenine pathway in depression and schizophrenia: convergent signals, divergent states, and clinical signatures.EXCLI journal · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe kynurenine pathway (KP) plays a pivotal role in many diseases that involve distinct pathological mechanisms.
objectivesSince KP metabolites are potential disease biomarkers, it is crucial to investigate their fluctuations under physiological conditions. As the KP is stress-responsive, this study examines how peripheral KP metabolites change with core temperature increases induced by two different modalities.
methodsIn this randomized cross-over study, 11 young healthy males were subjected to (a) exogenous heating via hot water immersion (44°C, EXO), and (b) exertional heating via exercise (EXE), until rectal temperature (T
resultsEXE and EXO trials induced the KP, but to different extents. Most plasma KP metabolite concentrations (kynurenic acid, picolinic acid, 3-hydrokynurenine, quinolinic acid) increased. Stress markers were elevated in both trials. Changes in KP metabolites, stress, and metabolic markers were not persistent, and returned to baseline following recovery.
conclusionAn elevation in body temperature by heat exposure or exercise increases peripheral concentration of several KP metabolites that return to baseline upon trial cessation, suggesting that KP enzymes are adaptable to physiological stressors.
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