Evidence map›Paper›PMID 41217934›Full record

ArticleCell reports2025

Endothelial IL-36 receptor activation promotes vascular stability to limit pathological microvessel permeability in the CNS.

Erin Fahey, Lucia Celkova, Valentina Frezza, Graeme P Sullivan, Kieran Byrne, Avril Watson, Yasmina E Hernandez-Santana, Kieva Byrne, Rachel Dalton, Hande Efe-Cicek and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Erin FaheyDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Lucia CelkovaDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Valentina FrezzaSmurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
Graeme P SullivanSmurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
Kieran ByrneDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Avril WatsonDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Yasmina E Hernandez-SantanaDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland; National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin, Ireland.
Kieva ByrneDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Rachel DaltonDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Hande Efe-CicekSmurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
Jeffrey O'CallaghanSmurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
Conor DelaneySmurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
Ema OzakiDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Patrick T WalshDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland; National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin, Ireland.
Seamus J MartinSmurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
Matthew CampbellSmurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
Sarah L DoyleDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland. Electronic address: sarah.doyle@tcd.ie.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathological increases in vascular permeability cause edema and swelling, driving retinal and neurological disorders. Few factors are known to specifically enhance barrier integrity and prevent fluid leakage. Here, we examine the effects of IL-36 receptor (IL-36R) activation on vascular permeability in vivo in mice, ex vivo in tissue explants, and in vitro in primary mouse and human microvascular endothelial cells. Using a soluble, biologically active DEVD-modified recombinant IL-36β cytokine, we find that the processed

Indexed as

Capillary PermeabilityCentral Nervous SystemEndothelial CellsMicrovesselsReceptors, Interleukin-1AnimalsHumansMiceMice, Inbred C57BLSignal TransductionTight JunctionsReceptors, Interleukin-1blood-retinal barrierchoroidal neovascularizationCP: neuroscienceIL-36 cytokineIL-36 receptorIL-36 receptor antagonistretinal neovascular diseasetight junctionsvascular permeabilityvascular stabilizationVE-cadherin

Identifiers

PMID41217934
PMCPMC12647355

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.