ArticleJournal of Alzheimer's disease : JAD2026
Uncovering pathology, subjective cognitive complaints, and sex in early Alzheimer's disease.
Article in Journal of Alzheimer's disease : JAD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Considerations in Alzheimer's Disease in Women.Current neurology and neuroscience reports · 2026Review
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Authors and funding
5 authors.
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Abstract
BackgroundSubjective cognitive complaints may correlate with cerebral amyloid-β (Aβ) levels in the early phases of Alzheimer's disease (AD). The relationship between sex, AD pathology, and complaints remains unclear.ObjectiveOur study aims to (1) explore the relationship between Aβ pathology, assessed with two complementary measures, and subjective cognitive complaints across multiple domains in cognitively unimpaired (CU) individuals and those with mild cognitive impairment (MCI); (2) assess which subjective cognitive complaints can differentiate Aβ-positive from Aβ-negative individuals, CU from MCI, and progressors from non-progressors; and (3) evaluate sex differences in these relationships.MethodsIn 418 CU older adults and 408 with MCI from the ADNI cohort, we examined associations between Aβ, subjective cognitive complaints and sex, controlling for age, education, depression, and anxiety.ResultsIn CU individuals, higher Aβ levels correlated with more severe language and visuospatial complaints. MCI individuals with elevated Aβ reported more severe memory, language, and planning complaints. Memory, language, planning, and organization complaints predicted risk of MCI and clinical progression. Sex differences emerged in the association between Aβ and visuospatial complaints, and in complaint types predicting Aβ positivity and cognitive impairment.ConclusionsSubjective cognitive complaints in memory and non-memory domains (language, visuospatial, and executive functions) may signal cognitive decline risk due to their association with AD biomarkers and clinical progression. Sex differences highlight the need for personalized approaches in AD early diagnosis and disease progression monitoring.
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