Evidence map›Paper›PMID 41217826›Full record

ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Complement Overactivation as a Causal Driver of Sepsis-Associated Coagulopathy: A Mendelian Randomization Study from the UK Biobank.

Rong Liufu, Mao-Mao Cao, Yan Chen, Yang-Yan-Qiu Wang, Yao Wu, Wei Jiang, Jin-Min Peng, Bin Du, Li Weng

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In one paragraph

Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rong LiufuState Key Laboratory of Complex Severe and Rare Diseases, Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.ORCID 0000-0002-7595-4234
Mao-Mao CaoState Key Laboratory of Complex Severe and Rare Diseases, Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
Yan ChenState Key Laboratory of Complex Severe and Rare Diseases, Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
Yang-Yan-Qiu WangState Key Laboratory of Complex Severe and Rare Diseases, Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
Yao WuState Key Laboratory of Complex Severe and Rare Diseases, Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
Wei JiangState Key Laboratory of Complex Severe and Rare Diseases, Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
Jin-Min PengState Key Laboratory of Complex Severe and Rare Diseases, Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
Bin DuState Key Laboratory of Complex Severe and Rare Diseases, Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
Li WengState Key Laboratory of Complex Severe and Rare Diseases, Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundThis study aimed to investigate the causal relationship between complement system overactivation and coagulopathy in sepsis using a two-sample Mendelian Randomization (MR) approach.MethodsWe conducted genome-wide association studies (GWAS) using UK Biobank data to identify genetic variants associated with high complement levels in sepsis patients (exposure) and with coagulopathy (outcome). Single nucleotide polymorphisms (SNPs) robustly associated with the exposure were used as instrumental variables in a bidirectional MR analysis to assess causality. The primary analysis utilized the inverse variance weighted (IVW) method, supplemented by extensive sensitivity analyses to test for pleiotropy. Multivariable MR (MVMR) was performed to adjust for the potential confounding effects of C-reactive protein (CRP), a key inflammatory marker.ResultsThe GWAS identified distinct and shared genetic loci for high-complement sepsis and coagulopathy, including in key complement (CFH, C3) and coagulation (F5) genes. The primary MR analysis revealed a significant positive causal effect of genetically predicted high C3 levels on the risk of developing coagulopathy (β = 0.62,

Indexed as

Blood Coagulation DisordersComplement ActivationMendelian Randomization AnalysisSepsisBiological Specimen BanksFemaleGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideUK BiobankUnited Kingdomcoagulopathycomplementmendelian randomization studysepsis

Identifiers

PMID41217826
PMCPMC12605881

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.