ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2026
Dietary Iron Intake and Risk of Gastric Cancer.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Dietary Lycopene Intake and Gastric Cancer Risk: Findings from a Case-Control Study.Nutrients · 2026Article
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13 authors.
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Abstract
backgroundIron is one of the essential elements for human life. Prior studies provided inconclusive results about the association between dietary iron intake and gastric cancer risk. We determined the association between dietary iron intake and the risk of gastric cancer in a case-control study of 1,182 incident gastric cancer cases and 2,965 controls in Vietnam.
methodsWe used a validated, semiquantitative food frequency questionnaire to obtain dietary information, including dietary iron intake. An unconditional regression model was used to calculate OR and 95% confidence intervals (95% CI) of gastric cancer in relation to dietary iron intake, adjusted for potential confounders.
resultsWe observed a U-shaped association between dietary iron intake and gastric cancer risk. Compared with category 2 (reference group), the ORs and 95% CIs of category 1 (lowest intake) and categories 3, 4, 5, and 6 were 1.64 (1.27-2.12), 1.17 (0.90-1.53), 1.35 (1.01-1.82), 1.65 (1.18-2.31), and 2.00 (1.36-2.95; Ptrend < 0.001), respectively. This U-shaped association was also observed in both sexes, in all types of dietary iron intake (i.e., heme and nonheme), and among individuals with noncardia gastric cancer. This pattern was more apparent among individuals with a body mass index < 23 kg/m2 (Pheterogeneity = 0.02), never smokers (Pheterogeneity = 0.02), those without a family history of cancer (Pheterogeneity = 0.99), and individuals with blood group O (Pheterogeneity = 0.98) but showed up in both alcohol and coffee drinkers.
conclusionsWe found a U-shaped association between dietary iron intake and gastric cancer risk. IMPACT: Results from our study also provide evidence for a tailored dietary intervention program that would benefit specific populations and those living in similar settings.
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