ArticleNetherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation2025
Men and women's hearts don't beat the same: Epicardial mapping of Bachmann's bundle.
Article in Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Fundamental Anatomy and its Impact on Clinical Practice: Bachmann's Bundle and Interatrial Conduction (Part I-III).JACC. Case reports · 2026Article
- Advancing cardiovascular care-key insights from the Netherlands Heart Journal 2025.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026Article
- Bridging the Gap: Time to Integrate Sex- and Gender-Specific Insights into Research and Practice.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundThere is increasing evidence that presentation, progression, and management of atrial arrhythmias, such as atrial fibrillation (AF), differ between women and men. Bachmann's bundle (BB) is the main route for interatrial conduction, and sex-related differences in structural and electrical remodeling of BB may contribute to differences in AF development between women and men.
objectiveInvestigate whether sex differences in the electrophysiological properties of BB assessed by high-resolution and density maps exist in patients with AF.
methodsSinus rhythm at BB was recorded for 5 s during cardiac surgery. Potential voltage, low-voltage area (LVA), conduction heterogeneity, unipolar potential morphology, and conduction velocity were assessed for both men and women.
resultsThe study population consisted of 108 patients (73 men, 35 women). Women had significantly lower potential voltages (5th percentile: 0.7 mV [0.6-1.0] vs 1.1 mV [0.6-1.4], p = 0.028), more LVAs (10.8% [4.6-19.7] vs 4.3% [2.2-11.7], p = 0.012) and more long double potentials (11.1% [3.6-13.5] vs 5.0% [1.0-10.3], p = 0.015) compared to men.
conclusionsWe observed sex-related differences in the electrical remodeling of BB in AF patients. Women have a higher proportion of low voltage potentials, and more abnormal potential morphologies compared to men. These findings may reflect sex-specific differences in the underlying substrate of AF at BB.
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