Evidence map›Paper›PMID 41217696›Full record

ArticleMolecular neurobiology2025

NLRP3 Inflammasome Activation Contributes to Seizure Susceptibility in Anti-NMDAR Encephalitis: Evidence from Patients and a Mouse Model.

Hanyu Luo, Jiaxin Yang, Yuhang Li, Honghong Song, Xiaoyue Yang, Ziyao Han, Dishu Huang, Li Cheng, Jiannan Ma, Li Jiang

Abstract read
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Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hanyu LuoDepartment of Neurology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Jiaxin YangDepartment of Neurology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Yuhang LiDepartment of Neurology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Honghong SongDepartment of Neurology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Xiaoyue YangDepartment of Neurology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Ziyao HanDepartment of Neurology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Dishu HuangDepartment of Neurology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Li ChengDepartment of Neurology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Jiannan MaDepartment of Neurology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China. mjn023@126.com.
Li JiangDepartment of Neurology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China. dr_jiangcqmu@163.com.

Funding

Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) 2025MSXM159Natural Science Foundation of Chongqing, China CSTB2024NSCQ-MSX0506
6 · The paper itself

Abstract

Seizures are common in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, yet the mechanisms beyond antibody-mediated NMDAR hypofunction remain poorly understood. This study investigated whether microglial NLRP3 inflammasome activation increases seizure susceptibility and whether its inhibition confers protection. In a pediatric cohort of sixty patients, serum levels of NLRP3 and IL-1β were elevated in patients compared with controls. Multivariable models indicated that NLRP3 was independently associated with seizure presence, whereas IL-1β did not retain independent significance when modeled alongside NLRP3, and model discrimination improved modestly when both markers were included. In an active-immunization mouse model using the GluN1

Indexed as

Anti-N-Methyl-D-Aspartate Receptor EncephalitisInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinSeizuresAdolescentAnimalsChildChild, PreschoolDisease Models, AnimalDisease SusceptibilityFemaleHumansInterleukin-1betaMaleMiceMice, Inbred C57BLInflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinAnti-NMDAR encephalitisMCC950MicrogliaNLRP3Seizure

Identifiers

PMID41217696

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.