ArticleMolecular biology reports2025
Transcriptional analysis of quorum sensing genes cviI/cviR and violacein synthesis genes in imipenem non-susceptible Chromobacterium violaceum.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCarbapenem resistance is a global public health issue, with quorum sensing playing a key role. Chromobacterium violaceum, a gram-negative opportunistic pathogen, has a quorum-sensing system that contributes to its antibiotic resistance and virulence. This study analyzes the expression of quorum-sensing genes cviI and cviR, and violacein synthesis genes, in imipenem non-susceptible isolates of C. violaceum under different growth conditions. METHODS AND
resultsThe bacterial isolates were screened for carbapenem non-suseptibility with 1 ug/ml imipenem screen agar. Two isolates of C. violaceum (CD_CV48 and CD_CV64) with reduced susceptibility to imipenem were selected for the study. Both isolates exhibited minimum inhibitory concentration (MIC) values above the breakpoint for imipenem. The non-susceptible isolates were assessed for the presence of various classes of carbapenemase genes by PCR which revealed the presence of the bla
conclusionsThe findings of this study highlight the complex relationship between quorum sensing and antibiotic resistance in C. violaceum. The differences observed in the transcriptional profiles of genes related to quorum sensing and violacein synthesis under varying growth conditions highlight the intricacies of bacterial regulatory networks.
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