Evidence map›Paper›PMID 41217648›Full record

ArticleDiscover oncology2025

Global research landscapes of ALDH2 and cancer revealed by bibliometric analysis.

Tongtong Zhang, Xiaodong Chen, Wenjie Yu, Zhe Yang, Yan-Dong Miao, Jiong Deng, Fang Zhang

Abstract read
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tongtong ZhangThe Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The 2nd Medical College of Binzhou Medical University, No. 717 Jinbu Street, Muping District, Yantai, 264100, Shandong, China.
Xiaodong ChenThe Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The 2nd Medical College of Binzhou Medical University, No. 717 Jinbu Street, Muping District, Yantai, 264100, Shandong, China.
Wenjie YuThe Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The 2nd Medical College of Binzhou Medical University, No. 717 Jinbu Street, Muping District, Yantai, 264100, Shandong, China.
Zhe YangThe Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The 2nd Medical College of Binzhou Medical University, No. 717 Jinbu Street, Muping District, Yantai, 264100, Shandong, China.
Yan-Dong MiaoThe Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The 2nd Medical College of Binzhou Medical University, No. 717 Jinbu Street, Muping District, Yantai, 264100, Shandong, China.
Jiong DengMedical Research Center, Binzhou Medical University Hospital, Binzhou, 256600, Shandong, China.
Fang ZhangThe Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The 2nd Medical College of Binzhou Medical University, No. 717 Jinbu Street, Muping District, Yantai, 264100, Shandong, China. zhangfang820127@163.com.

Funding

the Science and Technology Program of Yantai Affiliated Hospital of Binzhou Medical University BY2019KYQD49
6 · The paper itself

Abstract

Recent years have seen a marked increase in studies focusing on the mechanistic role of Aldehyde dehydrogenase 2 (ALDH2) genetic polymorphisms in tumors, yet this field lacks systematic bibliometric analysis. By analyzing publication years, countries/regions, research institutions, disciplinary domains, authorship networks, journal distributions, and keyword networks, this study reveals that global research interest in ALDH2 and tumors continues to rise. China, the United States, and Japan form the core contributing triangle, with institutions such as Aichi Cancer Center and Stanford University leading cutting-edge exploration. The research landscape concentrates on oncology, biochemistry and molecular biology, and cell biology, while interdisciplinary immunology provides innovative perspectives. Key future directions include elucidating the regulatory networks of ALDH2 polymorphisms in the metabolism-cancer axis and their associations with gastrointestinal and hematologic malignancies, alongside mechanistic studies encompassing oxidative stress modulation, ferroptosis regulation, DNA adduct formation, apoptotic cascades, DNA methylation, senescence-associated secretory phenotypes and tumor immune escape microenvironment dynamics.

Indexed as

Aldehyde dehydrogenase 2BibliometricCancerCitespaceScimago graphicaVOSviewer

Identifiers

PMID41217648
PMCPMC12616758

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.