Evidence map›Paper›PMID 41217615›Full record

ArticleApplied biochemistry and biotechnology2026

Glycyrrhizin Combined with Electroacupuncture Relieves Parkinson's Disease Progression Through the Inhibition of HMGB1-mediated Microglial Autophagy.

Ailan Pang, Hui Bian, Hao Fan, Houjun Zhou, Yanghong Zou, Xin Geng

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Article in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ailan PangDepartment of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China.
Hui BianDepartment of Physiology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, Yunnan, China.
Hao FanDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Kunming Medical University, Kunming, 650500, Yunnan, China.
Houjun ZhouNHC Key Lab of Drug Addiction Medicine, Kunming Medical University, Kunming, 650500, Yunnan, China.
Yanghong ZouNHC Key Lab of Drug Addiction Medicine, Kunming Medical University, Kunming, 650500, Yunnan, China.
Xin GengNHC Key Lab of Drug Addiction Medicine, Kunming Medical University, Kunming, 650500, Yunnan, China. gengxin@ydyy.cn.

Funding

Associated Project of Yunnan Province Science & Technology Department and Kunming Medical University Basic Research for Application 202301AY070001-209Geng Xin, a Project for the Training of Technological Innovation Talents in Yunnan Province 202205AD160006National Natural Science Foundation of China 82460236NHC Key Lab of Drug Addiction Medicine(Kunming Medical University) Open Projects Fund KN202409NHC Key Lab of Drug Addiction Medicine(Kunming Medical University) Open Projects Fund KN202418Youth Project of Basic Research Project of Yunnan Science and Technology Plan Project 202401AU070011Yunnan Health Training Project of High Level Talents Fund Supports the Yunnan Provincial Health Commission's Medical Discipline Leader Training Program D-2024043Yunnan Provincial Education Department Scientific Research Fund Project 2024J0183
6 · The paper itself

Abstract

backgroundMicroglial autophagy is closely related to the development of Parkinson's disease (PD). The objective of this research was to investigate the effect of glycyrrhizin (Gly) combined with electroacupuncture (EA) on PD mice and its potential regulation of microglial autophagy.

methodsA PD mouse model was constructed using the administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), followed by the administration of Gly to PD mice and EA. The activation of BV2 cells was triggered by lipopolysaccharide (LPS). Western blotting, immunofluorescence, flow cytometry, Nissl staining, and immunohistochemistry were used to investigate the molecular mechanism that governs how microglial autophagy levels influence PD progression.

resultsElevated levels of HMGB1 were observed in both patients with PD and PD mice. Gly inhibited HMGB1 expression and extracellular secretion by increasing SIRT1 activity and subsequently inhibit BV2 autophagy. EA inhibited the autophagy of microglia in PD mice by inhibiting the activation of TRPV1 and reducing the expression of HMGB1 in vivo. Gly combined with EA downregulated HMGB1 expression, inhibited microglial autophagy and improved the PD process, resulting in better effects than Gly or EA alone.

conclusionGly combined with EA can reduce the level of autophagy in microglia by downregulating HMGB1, thereby improving the PD process and providing a theoretical basis for the clinical treatment of PD.

Indexed as

AutophagyElectroacupunctureGlycyrrhizic AcidHMGB1 ProteinMicrogliaParkinson DiseaseAnimalsCell LineDisease Models, AnimalDisease ProgressionFemaleHumansMaleMiceMice, Inbred C57BLSirtuin 1Glycyrrhizic AcidHMGB1 ProteinHMGB1 protein, humanHMGB1 protein, mouseSirtuin 1TRPV Cation ChannelsElectroacupunctureGlycyrrhizinMicroglial autophagyParkinson’s disease, HMGB1

Identifiers

PMID41217615

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