Evidence map›Paper›PMID 41217592›Full record

ArticleDigestive diseases and sciences2026

Outcomes of Hospitalized Patients with Severe UC from 1997 to 2021 in a Large Regional Healthcare System in the US.

Katie Williams, Lauren A Sussman, Prasanna Challa, Emily W Lopes, Jonathan Downie, Michaela Tracy, Gregory Fricker, Erik Hasenoehrl, Rachel Irengo, Jenny Gurung and 9 more

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Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

19 authors.

Katie Williams *Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, 16 Floor, Boston, MA, USA.
Lauren A Sussman *Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, 16 Floor, Boston, MA, USA.
Prasanna ChallaClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA.
Emily W LopesDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, 16 Floor, Boston, MA, USA.
Jonathan DownieDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, 16 Floor, Boston, MA, USA.
Michaela TracyDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.
Gregory FrickerDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, 16 Floor, Boston, MA, USA.
Erik HasenoehrlDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, 16 Floor, Boston, MA, USA.
Rachel IrengoDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, 16 Floor, Boston, MA, USA.
Jenny GurungDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, 16 Floor, Boston, MA, USA.
Cecilia WooDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, 16 Floor, Boston, MA, USA.
Negin AmoueiDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, 16 Floor, Boston, MA, USA.
Yueting LuDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, 16 Floor, Boston, MA, USA.
Artemis TrikolaDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, 16 Floor, Boston, MA, USA.
Marc ShermanDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, 16 Floor, Boston, MA, USA.
Liliana BordeianouDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, 16 Floor, Boston, MA, USA.
Rocco RicciardiDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, 16 Floor, Boston, MA, USA.
Tracey SimonDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, 16 Floor, Boston, MA, USA.
Hamed KhaliliDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, 16 Floor, Boston, MA, USA. hkhalili@mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisease course following hospitalization for severe ulcerative colitis (UC) is poorly understood. Here, we evaluate the outcomes of hospitalized patients with severe UC defined using endoscopic activity across the Mass General Brigham (MGB) health system over a 24-year period.

methodsWe developed and internally validated a natural language processing (NLP) algorithm to derive endoscopic disease severity. We included all hospitalized patients with UC across MGB from 1997 to 2021 and used the NLP algorithm to identify those with severe disease activity, defined using the Mayo Endoscopic Score. We used Cox proportional hazards modeling to estimate the risk of 90-day colectomy and rehospitalization across three calendar periods (1997-2005, 2006-2015, and 2016-2021) for patients hospitalized with severe UC.

findingsThe NLP algorithm had excellent performance for identifying endoscopic features, with high Cohen's Kappa scores between the algorithm's prediction and the reviewers' consensus for derived Mayo endoscopic score (k = 0.92). We identified 279 independent hospitalizations for severe UC using our NLP algorithm and manual validation methods from 1997 to 2021. The 90-day cumulative incidence of colectomy were 17.9% in 1997-2005, 18.3% in 2006-2015 and 24.4% in 2016-2021. In contrast, rates of biologic medication use increased from 10.7% in 1997-2005 to 70.2% in 2016-2021. Compared to the 1997-2005 period, the adjusted hazard ratios (aHRs) for 90-day colectomy were 1.1 (95% CI 0.4-2.8) in 2006-2015 and 1.5 (95% CI 0.6-3.9) in 2016-2021 (P

interpretationHere, we present an NLP algorithm for extracting features of endoscopic severity in patients with UC. Using this algorithm, we showed that the outcomes, including colectomy and rehospitalization, of patients hospitalized for severe UC in a large health system in the US have not significantly changed over the past 24 years.

Indexed as

Colitis, UlcerativeHospitalizationAdultAgedAlgorithmsColectomyFemaleHumansMaleMiddle AgedNatural Language ProcessingPatient ReadmissionRetrospective StudiesSeverity of Illness IndexUnited StatesColectomyHospitalizationNLPOutcomesUlcerative colitis

Identifiers

PMID41217592

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.