ArticleInflammopharmacology2025
Evaluation of the oxidative stress reduction and anti-inflammatory efficacy of fractions of the methanolic extract of the leaf part of Ziziphus nummularia using complete Freund's adjuvant-induced arthritis in rats.
Article in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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4 authors.
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Abstract
introductionRheumatoid arthritis is a systemic immune-mediated disease characterized by persistent joint inflammation of multiple small and large joints mainly the joints of hands, feet, and knees. Medicinal plants remain a promising source for developing new anti-arthritic medications. This research evaluated the antioxidant and potential anti-arthritic effects of various fractions of methanolic extracts of Z. nummularia. MATERIALS: Evaluation was carried out using DPPH and the egg albumin denaturation method, followed by in vivo evaluation in a CFA-induced arthritis model in experimental rats.
resultsThe DPPH assay showed maximum % inhibition by the chloroform fraction of the methanolic extract of Z. nummularia with an IC DISCUSSION: Inflammatory macrophage and granulocyte migration was attenuated by the active fraction in a dose-dependent manner, alleviating the anemia commonly associated with arthritis. Histopathological and microscopic examinations of joint sections revealed that the diclofenac, 200 mg/kg AFID, and 400 mg/kg AFHD groups exhibited reduced necrosis and edema. Radiographic images of the hind paws showed that the high-dose active fraction significantly suppressed joint inflammation and slowed disease progression compared to diclofenac (standard).
conclusionOverall, the findings suggest that Z. nummularia represents a prospective source of natural therapeutics with antioxidant and anti-inflammatory properties, offering promising therapeutic effects for relieving various ailments related to inflammatory responses.
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