ArticleJournal of cancer research and clinical oncology2025
A clinical report and analysis of metachronous multiple primary cancers occurred in four sites.
Article in Journal of cancer research and clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Prediction of overall survival in patients with hepatocellular carcinoma and second primary malignancies: a prognostic model based on the SEER database.Translational cancer research · 2026Article
- Pembrolizumab plus Lenvatinib for Synchronous Triple Primary Malignancies of the Kidney, Bladder, and Liver: Clinical Implications of Conflict of Drug Doses and Dominant Tumor Biology.Case reports in oncologyArticle
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Authors and funding
4 authors.
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Abstract
purposeThis case report describes a rare occurrence of quadruple primary malignancies-specifically, bilateral primary breast cancer, ovarian cancer, and pleomorphic malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma-and explores its potential association with hereditary tumor syndromes.
methodsWe conducted a detailed clinical and histopathological analysis of the case. Repeated imaging and pathological examinations were performed to confirm the diagnosis of each primary malignancy.
resultsThe patient was diagnosed with four distinct primary tumors, and pathological evaluation confirmed each malignancy.
conclusionThis case emphasizes the importance of comprehensive pathological and genetic evaluation in patients with multiple primary malignancies. It highlights the growing incidence of such tumors among long-term cancer survivors and provides valuable insights for diagnosis and management in the context of hereditary cancer syndromes.
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