ArticleLangenbeck's archives of surgery2025
Is there a role for total neoadjuvant treatment in early-stage rectal cancer?
Article in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Organ preservation with total neoadjuvant therapy in early-stage rectal cancer: A statewide analysis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrent guidelines recommend surgical interventions for stage I rectal cancer (S1RC). Impaired functions and permanent colostomy remain undesirable outcomes, particularly in low-located stage I rectal cancer. Selective use of total neoadjuvant treatment (TNT) in S1RC may be a potential treatment option. STUDY
designPatients with S1RC who declined total mesorectal excision (TME) and opted for TNT between 2015 and 2023 were retrospectively reviewed. The study included two groups: (1) patients with S1RC who demonstrated a partial response following chemoradiation and chose consolidation chemotherapy, and (2) patients who underwent local excision of rectal lesions that were subsequently confirmed as S1RC but declined the recommended TME. Primary outcomes were complete response and organ preservation rates.
resultsThe study included sixteen S1RC patient (69% male) who underwent TNT. Eleven patients received TNT following partial response, while the remaining underwent TNT after transanal full-thickness local excision. In the first group (n = 11), nine patients achieved a complete clinical response. One patient with a near-complete response underwent endoscopic submucosal dissection, which revealed a tubulovillous adenoma. Another patient demonstrated a partial clinical response and subsequently underwent low anterior resection, with the final pathology showing a complete response. In patients who received TNT after local excisions, no local recurrence or distant metastasis was observed, with a median follow-up of 20 months (IQR 12). The overall complete response rate following TNT is 93.7%, and organ preservation rate of the study was 87.5%.
conclusionSelective utilization of TNT in S1RC holds the potential to foster organ preservation, particularly for low rectal cancer. Larger prospective studies with longer follow-up and standardized treatment protocols are needed to validate these preliminary findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.