Evidence map›Paper›PMID 41217423›Full record

ArticleHepatology (Baltimore, Md.)2025

Hepatic ischemia-reperfusion injury: Underlying mechanisms and concepts in liver surgery and liver transplantation.

Jie Zhao, Lidan Hou, Kenneth J Dery, Xiaoyi Yuan, Kang Ho Kim, Jerzy W Kupiec-Weglinski, David R Hall, Caitlin J Thornley, Mark J Hobeika, Holger K Eltzschig and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hepatology (Baltimore, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jie ZhaoDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0002-8795-2770
Lidan HouDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Kenneth J DeryDepartment of Surgery, University of California Los Angeles, Los Angeles, California, USA.
Xiaoyi YuanDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Kang Ho KimDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Jerzy W Kupiec-WeglinskiDepartment of Surgery, University of California Los Angeles, Los Angeles, California, USA.
David R HallDepartment of Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Caitlin J ThornleyDepartment of Surgery, University of California Los Angeles, Los Angeles, California, USA.
Mark J HobeikaDepartment of Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Holger K EltzschigDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Cynthia JuDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.

Funding

Role of Eosinophils in Hepatic Ischemia Reperfusion InjuryR01DK121330 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Cynthia Ju · 2019 to 2026
$3.3M
NIDDK NIH HHS R01 DK121330
6 · The paper itself

Abstract

Hepatic ischemia-reperfusion injury (H-IRI) is a critical complication in liver surgery and liver transplantation, contributing to graft dysfunction and poor clinical outcomes. When hepatocyte protective mechanisms are insufficient to counteract energy depletion and oxidative stress during ischemia, cell death occurs. Tissue damage during H-IRI leads to the release of damage-associated molecular patterns (DAMPs), which recruit and activate immune cells such as neutrophils and monocytes, orchestrating the initiation, progression, and eventual resolution of sterile inflammation. Extended criteria donor (ECD) livers, particularly steatotic ones, are more vulnerable to H-IRI, leading to poorer outcomes and limiting expansion of the donor pool. However, the mechanisms underlying this increased vulnerability are not yet fully understood. Emerging therapeutic strategies, including machine perfusion technologies, ischemic preconditioning, pharmacological interventions, and others, offer promise for mitigating H-IRI by either attenuating early injury triggers, enhancing intrinsic survival pathways, or restraining excessive inflammatory responses. Despite considerable progress in understanding H-IRI, further research is needed to identify additional therapeutic targets, particularly in the context of ECD livers, to develop effective, targeted interventions that can improve clinical outcomes.

Indexed as

hepatic ischemia–reperfusion injuryliver transplantationmyeloid cellsperfusion technologiessterile inflammation

Identifiers

PMID41217423
PMCPMC13179706

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.