Evidence map›Paper›PMID 41217191›Full record

ArticleClinical oral implants research2026

Antimicrobial-Releasing Implant Substrates for Combating Oral Biofilms: An In Vitro Study.

Nur Hidayatul Nazirah Kamarudin, Lars Vanmunster, Brecht Van Hooreweder, Kenneth Siemons, Kristel Bernaerts, Wim Teughels, Annabel Braem, Naiera Zayed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical oral implants research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nur Hidayatul Nazirah KamarudinDepartment of Materials Engineering, KU Leuven, Leuven, Belgium.
Lars VanmunsterDepartment of Mechanical Engineering, KU Leuven, Leuven, Belgium.
Brecht Van HoorewederDepartment of Mechanical Engineering, KU Leuven, Leuven, Belgium.
Kenneth SiemonsChemical and Biochemical Reactor Engineering and Safety, Department of Chemical Engineering, Leuven Chem&Tech, KU Leuven, Leuven, Belgium.ORCID 0000-0002-7967-4213
Kristel BernaertsChemical and Biochemical Reactor Engineering and Safety, Department of Chemical Engineering, Leuven Chem&Tech, KU Leuven, Leuven, Belgium.
Wim TeughelsDepartment of Oral Health Sciences, KU Leuven, Leuven, Belgium.
Annabel BraemDepartment of Materials Engineering, KU Leuven, Leuven, Belgium.ORCID 0000-0002-4890-0177
Naiera ZayedDepartment of Oral Health Sciences, KU Leuven, Leuven, Belgium.ORCID 0000-0002-7773-8199

Funding

European Union's Horizon Europe programKU Leuven
6 · The paper itself

Abstract

BACKGROUND AND

objectivesPeri-implantitis, a biofilm-associated inflammatory disease, significantly threatens dental implant longevity. Current treatments face limitations due to biofilm robustness. This study evaluates the efficacy of antimicrobial-releasing titanium-silica (Ti/SiO MATERIALS AND

methodsTi/SiO

resultsA mean pore diameter of 5.6 nm was observed for the discs, resulting in a steady drug release rate (≈0.00077 mmol/L CHX-DA/day). The antimicrobial-fed inserts showed less biofilm formation, with ≥ 2 log

conclusionAntimicrobial-releasing Ti/SiO

Indexed as

Anti-Infective AgentsBiofilmsChlorhexidineDental ImplantsPeri-ImplantitisAlloysAnti-Infective Agents, LocalHumansIn Vitro TechniquesMicroscopy, Electron, ScanningSilicon DioxideTitaniumAlloysAnti-Infective AgentsAnti-Infective Agents, LocalChlorhexidineDental ImplantsSilicon DioxideTitaniumtitanium alloy (TiAl6V4)anti‐bacterial agentsbiofilmsdental implantsdrug delivery systemsperi‐implantitis

Identifiers

PMID41217191
PMCPMC12875364

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.