Evidence map›Paper›PMID 41217165›Full record

ReviewMicrobiology and molecular biology reviews : MMBR2025

A roadmap to chemically reactive species: how diverse oxidants affect

Kara A Swenson, Luiz Alberti, Kaela Teele, Anshuman Yadav, Shivani J Shah, James B Konopka

Abstract readReview
In one paragraph

Review in Microbiology and molecular biology reviews : MMBR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Cascading damage toProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kara A SwensonDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
Luiz AlbertiDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
Kaela TeeleDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
Anshuman YadavDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
Shivani J ShahDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
James B KonopkaDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.ORCID 0000-0001-5989-4086

Funding

Regulation of Morphogenesis in C. albicansR01AI047837 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI James B Konopka · 2001 to 2026
$8.8M
C. albicans invasive growthR01AI177553 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI James B Konopka · 2024 to 2026
$2.0M
NIAID NIH HHS R01 AI047837NIAID NIH HHS R01 AI177553NIH HHS NIH R01AI047837NIH HHS NIH R01AI177553
6 · The paper itself

Abstract

SUMMARYFungal pathogens cause widespread disease in humans, plants, and animals. Surviving in diverse environments requires fungi to resist attack by a wide range of reactive chemicals, including reactive oxygen species, reactive nitrogen species, and redox-reactive metal ions. Some of these reactive species are from environmental sources or are the byproducts of cellular metabolism. However, in the case of human pathogens, a major threat is attack by the host immune system that employs chemically reactive species. Previous research on chemical attack by the immune system has often focused on hydrogen peroxide as a model oxidant. In this review, we will highlight recent advances in defining how the broad range of chemically reactive species generated by the immune system damage fungal cells, and the mechanisms used by cells to resist this attack. In particular, the pathways used by

Indexed as

Candida albicansFungiOxidantsReactive Oxygen SpeciesAnimalsCandidiasisHost-Pathogen InteractionsHumansHydrogen PeroxideOxidation-ReductionReactive Nitrogen SpeciesHydrogen PeroxideOxidantsReactive Nitrogen SpeciesReactive Oxygen SpeciesCandida albicanscatalaseflavodoxin-like proteinfungal pathogenglutathioneoxidative burstperoxidasereactive nitrogen speciesreactive oxygen speciesreactive speciesrespiratory burstROSsuperoxide dismutasethioredoxin

Identifiers

PMID41217165
PMCPMC12713398

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.