Evidence map›Paper›PMID 41216990›Full record

ArticleAging cell2025

PCBP2 Regulates p16

Shaoyang Yan, Lili Lu, Yuwei Wu, Zewen Du, Ebin Johny, Partha Dutta, Gang Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shaoyang YanAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lili LuAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Yuwei WuAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Zewen DuAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ebin JohnyCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Partha DuttaCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Gang LiAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Funding

Comprehensive functional genomic analysis of the multi-disease associated CDKN2A/B locusR01AG065229 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FINKEL, TOREN, LI, GANG · 2021 to 2025
$2.9M
NIA NIH HHS R01 AG065229NIH HHS R01AG065229
6 · The paper itself

Abstract

Recently, we have identified rs1333046 as one of the candidate functional single nucleotide polymorphisms (fSNPs) on the atherosclerosis-associated CDKN2A/B locus. However, how rs1333046 influences the pathogenesis of and susceptibility to atherosclerosis is unknown. In this work, we demonstrate that rs1333046 is part of a cis-regulatory element (cis-RE) that regulates p16

Indexed as

Cellular SenescenceCyclin-Dependent Kinase Inhibitor p16IronRNA-Binding ProteinsCD40 AntigensCells, CulturedGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsNF-kappa BPolymorphism, Single NucleotideProtein BindingSignal TransductionCD40 AntigensCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16IronNF-kappa BPCBP2 protein, humanRNA-Binding Proteins

Identifiers

PMID41216990
PMCPMC12686567

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.