Evidence map›Paper›PMID 41216873›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Epstein-Barr Virus Expressed Long Non-Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication.

Jiayan Liu, Dittman Lai-Shun Chung, Larry Ka-Yue Chow, Shuo Han, Wenkai Yi, Conor J Cremin, Yingyin Liao, Pui Wang, Bobo Wing-Yee Mok, Mingfang Ji and 3 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. EBV Genome Variations and Association With Diseases.Journal of medical virology · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiayan LiuState Key Laboratory for Emerging Infectious Diseases and Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.ORCID https://orcid.org/0009-0005-0996-1988
Dittman Lai-Shun ChungState Key Laboratory for Emerging Infectious Diseases and Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Larry Ka-Yue ChowDepartment of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Shuo HanSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Wenkai YiDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR, China.
Conor J CreminState Key Laboratory for Emerging Infectious Diseases and Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Yingyin LiaoState Key Laboratory for Emerging Infectious Diseases and Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Pui WangState Key Laboratory for Emerging Infectious Diseases and Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Bobo Wing-Yee MokState Key Laboratory for Emerging Infectious Diseases and Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Mingfang JiCancer Research Institute of Zhongshan City, Zhongshan People's Hospital, Zhongshan, Guangdong, China.
Jian YanDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR, China.
Wei DaiDepartment of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-5558-0685
Honglin ChenState Key Laboratory for Emerging Infectious Diseases and Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.ORCID https://orcid.org/0000-0001-5108-8338

Funding

General Research Fund 17102619General Research Fund 17119618Health@InnoHKITC funding support to State Key Laboratory for Emerging Infectious Diseases
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) is a ubiquitous human virus that is also linked to various human cancers. In EBV-associated nasopharyngeal carcinoma and gastric carcinoma cells, EBV expresses only essential viral antigens but high levels of long non-coding RNAs known as BamHI-A rightward transcripts (lncBARTs). The exact roles lncBARTs in the EBV life cycle and the development of EBV-associated cancers are largely not understood. This study demonstrates that lncBARTs play a role in maintaining viral genome replication by affecting the tethering of EBV oriP region to chromosome. Mechanistically, lncBARTs interact functionally with a complex consisting of Bromodomain-containing protein 4 (BRD4), CCTC-binding factor (CTCF), and EBV nuclear antigen 1 (EBNA1), anchoring their binding at oriP to facilitate EBV episome replication. Additionally, the lncBARTs-BRD4/CTCF complex contributes to the regulation of MYC and BCL2 expression. These findings suggest that lncBARTs modulate EBV latency through interactions with oriP region, while lncBARTs-BRD4/CTCF complexes promote host epigenome reprogramming and drive tumorigenesis in EBV-associated epithelial tumors.

Indexed as

Epstein-Barr Virus InfectionsGenome, ViralHerpesvirus 4, HumanRNA, Long NoncodingVirus LatencyVirus ReplicationCell Line, TumorGene Expression Regulation, ViralHumansRNA, Long NoncodingBRD4EBV copy numberEBV LncBARTsoncogenesis

Identifiers

PMID41216873
PMCPMC12884799

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.