Evidence map›Paper›PMID 41216865›Full record

ArticleEuropean journal of orthodontics2025

Studying the dynamics of mandibular growth spurts in individuals with Class I and Class II skeletal growth patterns using the Bayesian superimposition by translation and rotation (SITAR) model.

Satpal S Sandhu, George Leckie, Kate Tilling, Rachael A Hughes

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Article in European journal of orthodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Satpal S SandhuCentre for Multilevel Modelling, University of Bristol, 35 Berkeley Square, Clifton, Bristol BS8 1JA, United Kingdom.ORCID 0000-0002-8539-6897
George LeckieCentre for Multilevel Modelling, University of Bristol, 35 Berkeley Square, Clifton, Bristol BS8 1JA, United Kingdom.
Kate TillingMRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Clifton, Bristol BS8 2BN, United Kingdom.
Rachael A HughesMRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Clifton, Bristol BS8 2BN, United Kingdom.

Funding

Economic and Social Research Council S139511-120MRC Integrative Epidemiology Unit MC_UU_00011/3Wellcome Trust and the Royal Society 215408/Z/19/Z
6 · The paper itself

Abstract

backgroundComparing the mandibular growth patterns of Class I and Class II children offer valuable insights into adolescent growth dynamics that are crucial for planning growth modification procedures.

aimTo test the null hypothesis of no class differences (Class I vs. Class II) in mandibular growth spurt parameters (size, timing, intensity) versus clinically relevant differences defined as ≥ 5 mm for size, ≥ 1 year for timing, and ≥ 1 mm/year for intensity. SUBJECTS AND

methodsData (Condyle-Pogonion distance) available from the American Association of Orthodontists Foundation Craniofacial Growth Legacy Collection is analyzed. The dataset includes 160 children, 40 each in Class I and Class II groups for both sexes. A three-level Bayesian SITAR model is fitted, incorporating individual- and study-level random effects for all three growth spurt parameters.

resultsThe average mandibular size is greater in Class I than in Class II for both males [5.0 mm, 95% CI (3.0, 7.0)] and females [4.4 mm, 95% CI (3.2, 5.7)]. The growth spurt occurs later for Class I than Class II across both sexes [males: 0.6 years, 95% CI (0.3, 0.9); females: 0.6 years, 95% CI (0.2, 0.9)], and the intensity of the growth spurt is slightly greater in Class I than in Class II [males: 0.2 mm/year, 95% CI (0.0, 0.4); females: 0.2 mm/year, 95% CI (0.0, 0.4)]. The results show individual-level variation in size, timing, and intensity parameters across both Class II and Class I.

conclusionsNo evidence found for clinically meaningful class differences in the timing or intensity of the adolescent growth spurt dynamics for either sex. The mandibular deficiency observed in Class II children is established early, during the pre-adolescent growth period. The cumulative deficiency in mandibular size for Class II children worsens with age, which leads to a more pronounced skeletal discrepancy in adulthood. The clinical implications for treatment planning are discussed. LIMITATIONS: Considering the retrospective nature of the historical data analyzed, caution is warranted when generalizing our findings to contemporary populations.

Indexed as

Malocclusion, Angle Class IMalocclusion, Angle Class IIMandibleAdolescentBayes TheoremCephalometryChildFemaleHumansMaleMandibular CondyleSex FactorsBayesian growth modelingmandibular growth spurtSuperimposition by Translation and Rotation (SITAR) model

Identifiers

PMID41216865
PMCPMC12603614

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.