Evidence map›Paper›PMID 41216859›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

SLPI⁺ AT2-Like Cells Orchestrate Lung Adenocarcinoma Invasion via Wnt Pathway Activation and Stromal Crosstalk in a Spatially Defined Margin Niche.

Zhoufeng Wang, Guonian Zhu, Pan Tang, Yan Wang, Wenxin Luo, Wenpeng Song, Zhikang Pan, Bingjie Zheng, YongChao Jiang, Defu Xiao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhoufeng WangDepartment of Pulmonary and Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.ORCID https://orcid.org/0000-0002-7881-1837
Guonian ZhuDepartment of Pulmonary and Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Pan TangDepartment of Pulmonary and Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Yan WangDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Wenxin LuoDepartment of Pulmonary and Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Wenpeng SongDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Zhikang PanBGI Research, Shenzhen, 518085, China.
Bingjie ZhengBGI Research, Shenzhen, 518085, China.
YongChao JiangBGI Research, Chongqing, 401122, China.
Defu XiaoBGI Research, Shenzhen, 518085, China.
Xin JinState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, 518083, China.
Yong BaiState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, 518083, China.ORCID https://orcid.org/0000-0001-5960-8000
Guowei CheDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Weimin LiDepartment of Pulmonary and Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.ORCID https://orcid.org/0000-0003-0985-0311

Funding

1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University ZYGD22009Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences 2023-12M-2-001Key R&D Support Plan of Chengdu Science and Technology Bureau 2023-YF09-00039-SNNational Natural Science Foundation of China 32170592National Natural Science Foundation of China 32370628National Natural Science Foundation of China 92159302Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0529500Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0529502Science and Technology Project of Sichuan 2023NSFSC004Science and Technology Project of Sichuan 2024NSFSC0402State Key Laboratory Special Fund 2060204
6 · The paper itself

Abstract

The spatial organization of the tumor microenvironment (TME) profoundly influences cancer biology. However, the cell types and spatial distribution driving lung adenocarcinoma (LUAD) invasion remain poorly understood. By integrating spatially resolved transcriptomics with scRNA-seq data, we identify a novel secretory leukocyte protease inhibitor (SLPI)-expressing AT2-like subpopulation that localizes specifically at the invasive tumor margin, which drives the transition from minimally invasive (MIA) to invasive (IA) LUAD. Functional characterization reveals that SLPI-expressing AT2-like cells upregulated Dickkopf-1(DKK1), enhancing tumor cell stemness and epithelial-mesenchymal transition (EMT). Furthermore, spatially co-localized MRC1-expressing resident tissue macrophages (RTM-TAMs) secrete pro-tumor cytokines upon interaction with SLPI

Indexed as

Adenocarcinoma of LungLung NeoplasmsSecretory Leukocyte Peptidase InhibitorTumor MicroenvironmentWnt Signaling PathwayAnimalsCell Line, TumorEpithelial-Mesenchymal TransitionHumansNeoplasm InvasivenessSecretory Leukocyte Peptidase Inhibitormacrophageminimally invasive lung adenocarcinomaSLPIstemnesstumor microenvironment

Identifiers

PMID41216859
PMCPMC12866786

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.