ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Neuropsychiatric symptom phenotypes for early detection of risk in older adults.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Global and domain-specific cognitive intraindividual variability associations with neurodegenerative diagnoses and postmortem pathologies.Alzheimer's research & therapy · 2026Article
- Reframing Dementia Prevention Strategies Aligned with the WHO Global Action Plan: A Structured Narrative Review Focusing on Mild Behavioral Impairment.Neurology international · 2026Review
- Neuropsychiatric symptom phenotypes for early detection of risk in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Neuropsychiatric symptoms in mild cognitive impairment and early Alzheimer's disease: Clinical pattern and diagnostic implications.AIMS neuroscience · 2025Review
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Authors and funding
8 authors.
Funding
Abstract
introductionWe examined whether early neuropsychiatric symptom (NPS) patterns were associated with cognitive and neuropathologic changes.
methodsLatent class analysis within 20,599 cognitively unimpaired older adults in the National Alzheimer's Coordinating Center dataset identified NPS phenotypes. Progression to cognitive impairment, cognitive trajectories, and neuropathology across phenotypes were assessed.
resultsFour NPS phenotypes were identified: (1) Low-All, (2) High-Depression, (3) High-Agitation/Anxiety/Irritability (hAAI), and (4) High-All. Risk of progression to mild cognitive impairment (MCI)/dementia differed across phenotypes (Low-All < High-Depression < hAAI < High-All, p < 0.001). High-All and hAAI showed the lowest baseline performance and lower practice effects on cognitive tests, while High-Depression had persistently lower attention scores. The hAAI group had greater amyloid and neuritic plaque burden and higher arteriosclerosis severity compared to other groups (p < 0.01) DISCUSSION: Higher global NPS, and those with high agitation, anxiety, and irritability, showed greater odds of cognitive decline than depressive symptoms alone, underscoring the potential prognostic utility of early NPS patterns in predicting cognitive decline. HIGHLIGHTS: Identified four, data-driven neuropsychiatric symptoms (NPS) phenotypes in cognitively unimpaired older adults NPS phenotypes were differentially linked to progression, cognition, and pathology High-all and high-anxiety, agitation, and irritability had poorer baseline cognition NPS phenotypes may serve as early indicators of neurodegenerative disease risk.
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