ArticleActa crystallographica. Section F, Structural biology communications2025
Crystal structure of a short-chain dehydrogenase from Brucella ovis with apo and coenzyme NAD
Sean P Zupko, Amelia T Konstanty, Steve J Mayclin, Ryan Choi, Dmitry Serbzhinskiy, Emily Robles, Victoria Moses, Lynn K Barrett, Wesley C Van Voorhis, Tom E Edwards and 4 more
Abstract read
In one paragraphArticle in Acta crystallographica. Section F, Structural biology communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Sean P ZupkoDepartment of Chemistry, State University of New York at Cortland, Cortland, NY 13045, USA.ORCID 0009-0002-8568-5434 Amelia T KonstantyDepartment of Chemistry, State University of New York at Cortland, Cortland, NY 13045, USA.ORCID 0009-0001-3130-1231 Ryan ChoiSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA 98105, USA.ORCID 0000-0001-9374-5893 Dmitry SerbzhinskiySeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA 98105, USA.
Emily RoblesAllegheny College, Meadville, PA 16335, USA.
Victoria MosesJacksonville State University, Jacksonville, AL 36265, USA.
Lynn K BarrettDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Wesley C Van VoorhisSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA 98105, USA.ORCID 0000-0001-6141-2015 Peter J MylerSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA 98105, USA.ORCID 0000-0002-0056-0513 Katherine A HicksDepartment of Chemistry, State University of New York at Cortland, Cortland, NY 13045, USA.
Funding
Centers for Research on Structural Biology of Infectious Diseases: Universal Influenza Vaccine Research75N93022C00036 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI STAKER, BART · 2022 to 2025
$21.7MNational Science Foundation 2042704National Science Foundation 2050740National Science Foundation 2051087National Science Foundation 2149978NIAID NIH HHS 75N93022C00036NIAID NIH HHS HHSN272200700057CNIAID NIH HHS HHSN272201200025CNIAID NIH HHS HHSN272201700059C
6 · The paper itselfAbstract
Short-chain dehydrogenases (SDRs) are a family of NAD(P)-dependent enzymes involved in redox reactions, specifically carbonyl-alcohol reductions. Here, we report the apo and NAD
Indexed as
Bacterial ProteinsNADAmino Acid SequenceApoenzymesCatalytic DomainCloning, MolecularCrystallography, X-RayEscherichia coliGene ExpressionModels, MolecularProtein BindingProtein ConformationRecombinant ProteinsApoenzymesBacterial ProteinsNADRecombinant Proteinscoenzyme bindingredox chemistryresearch experience for undergraduatesshort-chain dehydrogenase/reductasesSSGCID
Identifiers
PMID41216818
PMCPMC12810213
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