Trial reportThe International journal of eating disorders2026
Shared Versus Unique Features of Neural Activation During Cognitive Flexibility Across Restrictive Eating Disorder Presentations.
Trial report in The International journal of eating disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The trial behind it
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Who cites it
1 citing paper in PubMed.
- Shared Versus Unique Features of Neural Activation During Cognitive Flexibility Across Restrictive Eating Disorder Presentations.The International journal of eating disorders · 2026Trial
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Authors and funding
20 authors.
Funding
Abstract
objectiveRestrictive eating disorders (EDs), including anorexia nervosa (AN) and atypical AN (Atyp-AN), are often associated with cognitive rigidity that can impede treatment. The dorsolateral prefrontal cortex (dlPFC) plays a central role in cognitive control, but it remains unclear whether its activation during cognitive flexibility will differ across restrictive ED presentations.
methodEighty-seven females with restrictive EDs (aged 14-35) (AN: n = 31; atyp-AN with history of AN [hx-AN]: n = 33; atyp-AN without history of AN [Atyp-AN]: n = 23) completed a task-switching paradigm during functional magnetic resonance imaging. We examined dlPFC activation during sustained (task-switching vs. completing a single task) and transient control (switching between task rules vs. repeating the same rule), testing for group differences and symptom associations.
resultsThe AN group showed a greater difference in left dlPFC activation during task switching vs. the single task compared to the hx-AN and Atyp-AN groups, driven by reduced activation during the single task condition. All groups showed similar increases in dlPFC activation during task switching and no differences in task performance. Across all participants, higher dlPFC activation during task switching vs. single task was associated with greater restraint symptoms. DISCUSSION: These novel findings identified shared versus unique neural features of sustained and transient control across restrictive ED groups. Heightened dlPFC activation during transient control associated with restraint may represent a transdiagnostic feature shared across restrictive EDs. Alternatively, reduced dlPFC activation during the low-demand, single-task condition in those with typical, but not atypical AN, may reflect a difference in sustained control, with implications for tailoring interventions to distinct restrictive ED presentations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.