Evidence map›Paper›PMID 41216782›Full record

ArticleAnimal models and experimental medicine2026

Continuous electrocardiogram monitoring in porcine model of myocardial ischemia reperfusion.

Nathaniel Hyams, Roxanne Swagel, Sharon Thomas, Rupak Mukherjee, Alicia Braxton Hickman, Daniel Eldridge, Kristine Helke, Ying Mei, Jean Marie Ruddy

Abstract read
In one paragraph

Article in Animal models and experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nathaniel HyamsDepartment of Bioengineering, Clemson University, Clemson, South Carolina, USA.
Roxanne SwagelDepartment of Lab Animal Resources, Medical University of South Carolina, Charleston, South Carolina, USA.
Sharon ThomasDepartment of Lab Animal Resources, Medical University of South Carolina, Charleston, South Carolina, USA.
Rupak MukherjeeDivision of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Alicia Braxton HickmanDepartment of Lab Animal Resources, Medical University of South Carolina, Charleston, South Carolina, USA.
Daniel EldridgeDepartment of Lab Animal Resources, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0003-4443-7696
Kristine HelkeDepartment of Lab Animal Resources, Medical University of South Carolina, Charleston, South Carolina, USA.
Ying MeiDepartment of Bioengineering, Clemson University, Clemson, South Carolina, USA.
Jean Marie RuddyDivision of Vascular Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0002-4148-9549

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
Nanowired human isogenic cardiac organoids to treat acute myocardial ischemia/reperfusion injuriesU01HL169361 · NHLBI · CLEMSON UNIVERSITY · PI MEI, YING · 2023 to 2024
$746k
College of Graduate Studies, Medical University of South Carolina SCTR 2305NHLBI NIH HHS 1U01HL169361-01NHLBI NIH HHS U01 HL169361NIH: NCATS UL1TR001450
6 · The paper itself

Abstract

As cardiovascular disease is the leading cause of global mortality, innovative animal models are vital to demonstrating the translational value of experimental discoveries. Investigations focused on myocardial remodeling after ischemia reperfusion (I/R) are well suited to a porcine model, but the evolution of that injury and its impact on electrical conductivity or arrhythmia threshold have been difficult to monitor continuously. Multiple electrode telemetry devices may be fitted to the animals but are costly and prone to damage. Implantable telemetry devices are likewise expensive, carry surgical risk, and are often verified only for single use. Here, we report the utilization of the commercially available Fourth Frontier X2 external telemetry device for continuous monitoring of heart rate and rhythm after myocardial I/R injury in pigs, highlighting sustained monitoring across a 7-day study.

Indexed as

ElectrocardiographyMyocardial Reperfusion InjuryTelemetryAnimalsDisease Models, AnimalHeart RateSwinebiotechnologycardiovascular biologyveterinary research

Identifiers

PMID41216782
PMCPMC13042709

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.