ArticlePlant biotechnology journal2026
Heat Shock Transcription Factor OsHsfc1a Enhances Rice Seedling Thermotolerance by Regulating OsMFT1 and Preserving Chloroplast Structure Under Heat Stress.
Article in Plant biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Genome-wide analysis of the HSF gene family in lily and functional characterization of LdHSFC1 under heat stress.Plant cell reports · 2026Article
- Epigenetic-epitranscriptomic crosstalk through TaHAG1-TaNSUN2 coordinates thermotolerance in wheat.Nature communications · 2026Article
- Applications of Gene-Editing Technologies in Enhancing Crop Stress Resistance with Emphasis on Rice.Plants (Basel, Switzerland) · 2026Review
- Transcriptomic and DNA methylation insights into polyploidy-enhanced heat tolerance in rice (Oryza sativa L.).Plant physiology · 2026Article
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Authors and funding
12 authors.
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Abstract
High-temperature stress severely threatens rice (Oryza sativa L.) growth and productivity, particularly during the seedling stage, making heat tolerance an essential breeding target. In this study, we identified the heat shock transcription factor OsHsfc1a as a positive regulator of thermotolerance in rice seedlings. OsHsfc1a expression was strongly induced by heat stress, and overexpression lines exhibited enhanced heat tolerance, whereas knockout mutants were hypersensitive. Integrative transcriptome and DAP-seq analyses revealed that OsHsfc1a directly binds to and represses the transcription of OsMFT1, a gene previously implicated in stress responses. Molecular and genetic assays confirmed that OsHsfc1a-mediated suppression of OsMFT1 helps maintain the chloroplast structural integrity, reduces reactive oxygen species accumulation, and alleviates programmed cell death under heat stress. In contrast, OsMFT1 overexpression impaired chloroplast organization and decreased seedling survival, whereas its knockout enhanced heat tolerance. Furthermore, comparative transcriptome analysis revealed that the OsHsfc1a-OsMFT1 regulatory module maintains the chloroplast structural integrity during heat stress by modulating the expression of multiple chloroplast structure-related genes. Analysis of natural haplotypes revealed that OsHsfc1a allelic variation is associated with rice subspecies differentiation, providing useful genetic resources for breeding heat-resilient varieties. In summary, we demonstrate that OsHsfc1a enhances heat tolerance by repressing OsMFT1 to preserve chloroplast stability, providing both mechanistic insights and practical genetic resources for rice improvement under global warming.
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