ArticleInternational journal of cardiology. Cardiovascular risk and prevention2025
Age-stratified optimal non-HDL cholesterol and all-cause mortality in a healthy Taiwanese population considering personal risk factors.
Article in International journal of cardiology. Cardiovascular risk and prevention, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Non-high-density lipoprotein cholesterol (non-HDL-C) is a key cardiovascular risk factor, yet its optimal range in healthy individuals remains unclear. Methods: This study analyzed data from 134,343 adults aged 40-79 in the MJ Health Check-up Cohort in Taiwan (2000-2017). Participants with prior cardiovascular disease or extreme/incomplete BMI data (≥50 kg/m Results: The mean age was 51.8 years, and 47.3 % were male. Most participants (62.7 %) had a BMI of 18.5-25. The average non-HDL-C level was 146.8 mg/dL. A U-shaped association was observed between non-HDL-C levels and all-cause mortality. Compared with the reference group (160-179 mg/dL), non-HDL-C levels of <100, 100-119, 120-139, and ≥200 mg/dL were linked to elevated mortality risk, with hazard ratios (HR) of 1.42 (95 % CI: 1.31-1.54), 1.19 (1.11-1.27), 1.11 (1.04-1.18), and 1.11 (1.03-1.20), respectively. The highest risk was noted in the 40-49 age group with non-HDL-C ≥200 mg/dL, particularly among females (HR 1.72, 95 % CI: 1.15-2.58). However, no significant increase in risk was observed for the same category in older age groups. Conclusions: A non-HDL-C range of 160-179 mg/dL was associated with the lowest all-cause mortality among healthy Taiwanese adults. Both lower and higher levels were linked to increased mortality risk, highlighting the importance of maintaining moderate non-HDL-C levels to support longevity and overall health.
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