ArticleEndoscopy international open2025
Risk factors for dysplastic lesions in the proximal stomach in patients with familial adenomatous polyposis.
Article in Endoscopy international open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Systematic gastric surveillance in patients with familial adenomatous polyposis.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2026Article
- Longitudinal Surveillance of Gastric Polyposis in Familial Adenomatous Polyposis: Incidence, Progression, and Endoscopic Outcomes.United European gastroenterology journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and study aims: Gastric cancer is a recently recognized challenge in management of familial adenomatous polyposis (FAP), mostly developing in the proximal stomach amid carpeting fundic gland polyposis. Dysplastic lesions in the proximal stomach might be the precursor lesions for gastric cancer in FAP. We aimed to describe incidence of dysplastic lesions in the proximal stomach and to identify risk factors for these dysplastic lesions. Patients and methods: Data were collected from FAP patients who had undergone esophagogastroduodenoscopy (EGD) between 2015 and 2023 at our academic center. To identify putative risk factors for dysplastic lesions in the proximal stomach, we used multivariable Cox proportional hazard regression modeling. Results: Among the 196 FAP patients who underwent EGD at our center, 33 (17%) were diagnosed with dysplastic lesions in the proximal stomach. In total 61% were female and median age at diagnosis was 49 years (range 19-80). A total of 105 dysplastic lesions were identified. Ten (9.5%) showed high-grade dysplasia. During the study period, seven patients were diagnosed with gastric cancer. Carpeting fundic gland polyposis (≥ 100 polyps) (hazard ratio [HR] 8.94; Conclusions: Carpeting fundic gland polyposis, biliary reflux, and use of PPIs were identified as putative risk factors for dysplastic lesions in the proximal stomach. Presence of these risk factors should alert endoscopists to assess the stomach more thoroughly.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.