ArticleiScience2025
TLR ligand sensing by lymph node FRCs directs intranodal lymphocyte accumulation to promote immune responses.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Functional responses of lymphoid stromal cells to Toll-like receptor stimuliDiscovery immunology · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune protection depends on antigen-responsive lymphocytes finding their cognate antigen on competent antigen-presenting cells. To increase the likelihood of such an event happening, lymphocytes transiently accumulate in secondary lymphoid organs soon after infection. Here, we show that this phenomenon requires expression of Toll-like receptors (TLRs) on lymph node stromal cells. Direct sensing of pathogen-associated molecular patterns by TLR-expressing fibroblastic reticular cells (FRCs) rapidly induced homeostatic chemokine expression, mediating immediate lymphocyte accumulation into reactive lymph nodes. Ablation of this response, by means of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.