Evidence map›Paper›PMID 41216428›Full record

ArticleMolecular therapy. Nucleic acids2025

SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes differential accumulation of HIF1ɑ and phosphorylated tau.

Pinja Kettunen, Janika Ruuska, Tania Quirin, Ravi Ojha, Saber H Saber, Julian D J Sng, Sean Morrison, Bahaa Al-Mhanawi, Mohammed R Shaker, Simon De Neck and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Pinja KettunenHelsinki Institute of Life Science (HiLIFE), Neuroscience Center, University of Helsinki, Helsinki, Finland.
Janika RuuskaDepartment of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Tania QuirinDepartment of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Ravi OjhaDepartment of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Saber H SaberAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
Julian D J SngSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Sean MorrisonDepartment of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Bahaa Al-MhanawiDepartment of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Mohammed R ShakerDepartment of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Simon De NeckLaboratory for Animal Model Pathology, Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Anja KiparLaboratory for Animal Model Pathology, Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Lassi PaavolainenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Ernst WolvetangDepartment of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Merja JoensuuAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
Jari KoistinahoHelsinki Institute of Life Science (HiLIFE), Neuroscience Center, University of Helsinki, Helsinki, Finland.
Taisia RolovaHelsinki Institute of Life Science (HiLIFE), Neuroscience Center, University of Helsinki, Helsinki, Finland.
Giuseppe BalistreriHelsinki Institute of Life Science (HiLIFE), Neuroscience Center, University of Helsinki, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been shown to infect areas of the human brain and a subset of neurons

Indexed as

antiviralsCA-004 MEcathepsinsHIF-1αmicrogliaMT: Clinical ApplicationsneurodegenerationSARS-COV-2tauvirus entry

Identifiers

PMID41216428
PMCPMC12597281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.