ArticleOpen forum infectious diseases2025
HIV Pre-exposure Prophylaxis Does Not Increase Gonorrhea and Chlamydia Incidence in Young Black and Hispanic Men who Have Sex With Men: An Observational Cohort Study.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: HIV pre-exposure prophylaxis (PrEP) use has been linked with increases in sexually transmitted infection (STI) incidence. Despite efforts to expand PrEP uptake among young Black and Hispanic men who have sex with men (YBHMSM), little research has been done to understand the impact of PrEP on STI incidence within these communities. We examine the effect of PrEP use on gonorrhea and chlamydia (NG/CT) incidence, condom use, and external STI testing (ie, outside of study visits). Methods: In a longitudinal cohort of HIV-negative YBHMSM (ages 16-24 years), we modeled the effect of PrEP use on study-external STI testing and number of condomless sex partners during the following 6 months using mixed-effects generalized linear models. We modeled the effect of PrEP use on NG/CT incidence using time-updated proportional hazard regression. Results: While on PrEP compared with periods not on PrEP, participants reported on average 2.51 (adjusted beta; 95% CI, 1.51-3.51; Conclusions: Condomless sex increased with PrEP use; however, its potential to elevate STI acquisition or prolonged duration of infection may be mitigated by PrEP-associated routine testing. Efforts to expand PrEP uptake among YBHMSM appear unlikely to exacerbate the STI epidemic.
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