ArticleBioactive materials2026
Versatile smart hydrogels for spatiotemporal drug delivery to orchestrate diabetic bone regeneration.
Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Hierarchical Nanoplatform Integrating Oxidative-Acidic Microenvironment Remodeling and Bone Homeostasis Modulation for Diabetic Bone Defect Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nuciferine-Loaded Lipid Nanoparticle Microneedles Alleviate Intervertebral Disc Degeneration by Restoring Nucleus Pulposus Cell Homeostasis.Pharmaceutics · 2026Article
- Injectable Mn-Icariin-functionalized silk fibroin/PEG hydrogels restore redox homeostasis and reprogram osteogenic-angiogenic coupling for diabetic bone regeneration.Regenerative biomaterials · 2026Article
- Biomaterial regulation of excessive inflammation restores osteoimmune homeostasis in diabetic bone regeneration.Regenerative biomaterials · 2026Review
- A pH-Responsive Polysaccharide Hydrogel Modulates Oxygen Delivery and Immunometabolic Remodeling for Diabetic Bone Regeneration.Research (Washington, D.C.) · 2026Article
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Authors and funding
18 authors.
Funding
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Abstract
Hyperglycemia-induced oxidative stress accelerates bone senescence, presenting a major challenge for diabetic bone regeneration. In this study, we developed a smart hydrogel by crosslinking hyaluronic acid (HA) grafted with 3-aminophenylboronic acid (HA-PBA) and polyvinyl alcohol (PVA) via phenylboronic acid ester bonds, incorporating metformin (Met), and anchoring parathyroid hormone-related peptide-1 (PTHrP-1) onto polydopamine (PDA)-hybridized nanosized zeolitic imidazolate framework-8 (P1@PZIF-8) to improve the osteogenic microenvironment and repair diabetic bone defects. Incorporation of PZIF-8 shortened gelation time and enhanced the mechanical strength of the HPA hydrogel. The system enabled dynamic, spatiotemporal drug release: >80 % of Met was released within 12 days, while PTHrP-1 and Zn
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