Evidence map›Paper›PMID 41216374›Full record

ArticleBioactive materials2026

Robust adhesive, antibacterial, pro-angiogenic and osteogenic bone adhesives with moderate degradability facilitating bone regeneration.

Wenhao Hu, Tianjiao Mao, Jinxu Chen, Peihong Hou, Jiayan Wu, Zhihao Ma, Yunhuan Li, Chao Xue, Xuesong Zhang

Abstract read
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenhao HuDepartment of Orthopaedics, The Fourth Medical Center, Chinese PLA General Hospital, Beijing, 100048, China.
Tianjiao MaoMedical School of Chinese PLA, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Jinxu ChenThe Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, 511400, China.
Peihong HouMedical School of Chinese PLA, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Jiayan WuDepartment of Orthopaedics, The Fourth Medical Center, Chinese PLA General Hospital, Beijing, 100048, China.
Zhihao MaDepartment of Orthopedics, Chinese PLA General Hospital, Beijing, 100853, China.
Yunhuan LiBeijing Biosis Healing Biological Technology Co., Ltd, Beijing, 102600, China.
Chao XueDepartment of Orthopaedics, The Fourth Medical Center, Chinese PLA General Hospital, Beijing, 100048, China.
Xuesong ZhangDepartment of Orthopaedics, The Fourth Medical Center, Chinese PLA General Hospital, Beijing, 100048, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional bone repair technologies such as using metal implants and autologous bone grafts, are limited due to immune rejection, donor availability, the need for secondary surgeries, and material fatigue. Here, we demonstrated a novel multifunctional bone adhesive by mixing poly (ethylene glycol) succinimidyl glutarate (PEG-SG) with tannic acid (TA), copper oxide (CuO), bioactive glass (BG), and gelatin for sealing cranial defects and facilitating bone regeneration. In the porous bone adhesive, the PEG-SG was formed into an interconnected matrix, while TA served as a polyphenolic crosslinker that reinforced interfacial adhesion and mechanical strength. The PEG-SG/TA/CuO/BG/Gel bone adhesive was biodegradable and bioactive by releasing Cu

Indexed as

AntibacterialBone adhesiveBone fractureBone regenerationOsteogenic differentiation

Identifiers

PMID41216374
PMCPMC12596665

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.