ArticleInternational journal of nanomedicine2025
A pH/H
Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study developed a dual-responsive nano-delivery system to overcome elevated glutathione (GSH) and acidic pH in the tumor microenvironment (TME), enhancing chemodynamic therapy (CDT) and chemotherapy against triple-negative breast cancer (TNBC). Methods: A pH/H Results: Characterization results (particle size, zeta potential, FTIR, TEM, XRD, and XPS) confirmed ZMDBS as a novel cobalt/manganese-based nanocomposite, with the encapsulation rate of 95%. It efficiently depleted GSH, enhanced ROS production, and controlled DOX release under TME conditions. In vitro experiments, ZMDBS showed minimal toxicity to LO2 hepatocytes, whereas induced a two-fold ROS increase, 70.7% apoptosis in 4T1 cells (vs 40.9% for DOX), and a lower IC Conclusion: ZMDBS, a pH/H
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.