ArticleTranslational gastroenterology and hepatology2025
Sex disparities in liver transplantation for hepatocellular carcinoma: long-term outcomes and recurrence predictors.
Article in Translational gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Addressing gender-based disparities in liver transplantation: A global analysis of surgical access and donor organ allocation.World journal of transplantation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: With a 2- to 3-fold higher incidence in men, hepatocellular carcinoma (HCC) is the leading indication for liver transplantation (LT). Despite this sex disparity in HCC incidence, the influence of recipient sex on long-term LT outcomes, including HCC recurrence, is not well established. This study investigates the impact of recipient sex on the long-term outcomes following LT for HCC. Methods: All consecutive patients undergoing LT for HCC between 2005 and 2018 were retrospectively analyzed. Data regarding patient demographics, tumor characteristics, and post-transplant outcomes were collected, and recipients were stratified by sex. Kaplan-Meier analysis was used to assess overall and recurrence-free survival (RFS). Multivariable Cox regression models were then used to determine independent predictors of HCC recurrence within each sex group. Results: Of the 384 adult recipients (mean age was 58.7±8.4 years and mean follow-up of 86.5±51.5 months), 17.2% of patients were female. The main etiology of cirrhosis in the female and male groups was alcohol-related (19.7%, 36.5%), HCV (40.9%, 24.5%) and metabolic dysfunction-associated steatohepatitis (MASH) (10.6%, 12.3%). The Model for End-Stage Liver Disease (MELD) and Child-Pugh scores were similar in both groups. 87.9% and 76.4% of the patients were within the Milan criteria and 95.5% and 91.5% of the patients had an alpha-fetoprotein (AFP) score ≤2 at the time of LT, respectively. The 1-, 3-, 5-, 10- and 15-year survival rates were similar in the male and female groups (91.5%, 81.5%, 72.4%, 57.7% and 44.9% Conclusions: Recipient sex does not impact long-term survival or HCC recurrence after LT. However, sex-specific predictors of HCC recurrence were identified: AFP score >2 and prior hepatectomy in females, and these plus diabetes mellitus and older age in males. Furthermore, female recipients presented with a significantly lower incidence of alcohol-associated cirrhosis as the underlying cause of HCC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.