Evidence map›Paper›PMID 41216176›Full record

ArticleThe Lancet regional health. Southeast Asia2025

CKDu-AGRI Study-a population-based cross-sectional study of chronic kidney disease and chronic kidney disease of unknown aetiology among agricultural workers in Tamil Nadu, India.

Natarajan Gopalakrishnan, Subramaniam Sudharshini, Ramanathan Sakthirajan, Thanigachalam Dineshkumar, Tanuj Moses Lamech, Anavarathan Somasundaram, Seshadri Jayalakshmi, Uma Maheswari, Sivadoss Raju, Mookaiah Seenivasan and 8 more

Abstract read
In one paragraph

Article in The Lancet regional health. Southeast Asia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Kidney health for all: Caring for people, protecting the planet.Journal of family medicine and primary care · 2026
    Article
  3. Article
  4. Kidney Health for all: Caring for People, Protecting the Planet.Canadian journal of kidney health and disease · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Natarajan GopalakrishnanInstitute of Nephrology, Madras Medical College, Member-Secretary, Transplant Authority of Tamil Nadu (TRANSTAN), India.
Subramaniam SudharshiniInstitute of Community Medicine, Madras Medical College, India.
Ramanathan SakthirajanInstitute of Nephrology, Madras Medical College, India.
Thanigachalam DineshkumarInstitute of Nephrology, Madras Medical College, India.
Tanuj Moses LamechInstitute of Nephrology, Madras Medical College, India.
Anavarathan SomasundaramDirectorate of Public Health and Preventive Medicine, Chennai, India.
Seshadri JayalakshmiInstitute of Nephrology, Madras Medical College, India.
Uma MaheswariInstitute of Community Medicine, Madras Medical College, India.
Sivadoss RajuDirectorate of Public Health and Preventive Medicine, Chennai, India.
Mookaiah SeenivasanInstitute of Nephrology, Madras Medical College, India.
Venkatesh ArumugamInstitute of Nephrology, Madras Medical College, India.
Nandakumar NachimuthuInstitute of Community Medicine, Madras Medical College, India.
Janani SuryaScientist C, Indian Council of Medical Research - National Institute of Epidemiology, Chennai, India.
Suliankatchi Abdulkader RizwanScientist D, Indian Council of Medical Research - National Institute of Epidemiology, Chennai, India.
Vishwanathan RamasubramaniamDepartment of Nephrology, Tirunelveli Medical College, India.
Rajendran Kasirajan ManorajanDepartment of Nephrology, Madurai Medical College, India.
Ayyakkannu Indirani NigazhFormer Researcher at MARETEC (Marine, Environment and Technology Centre), Lisbon.
Sivaprakasam T SelvavinayagamDirectorate of Public Health and Preventive Medicine, Chennai, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic kidney disease of unknown cause (CKDu) has been reported in "hotspots" around the world and linked to occupational heat stress, exposure to agrochemicals and environmental toxins. This was a systematic, statewide, population-based, observational study of agricultural workers in Tamil Nadu, to estimate the prevalence of chronic kidney disease (CKD) and CKDu. Methods: The state of Tamil Nadu was divided into five agroclimatic zones and stratified multi-stage cluster sampling was performed to select a representative study population. All participants underwent clinical evaluation and laboratory testing (Phase 1). Repeat sampling was performed after 3 months for all individuals with an eGFR <60 mL/min per 1.73 m Findings: Among 3350 participants who were screened, the number of participants with eGFR ≤60 mL/min per 1.73 m Interpretation: The prevalence of CKD among agricultural workers in Tamil Nadu is 5.31%, with about half of these due to CKDu. The effect of transient subclinical AKI on CKD progression needs further study. Funding: Tamil Nadu Health System Reform Program, Department of Health and Family Welfare, Government of Tamil Nadu.

Indexed as

Agricultural workersCKDuHeat stress

Identifiers

PMID41216176
PMCPMC12597305

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.