Evidence map›Paper›PMID 41216160›Full record

ArticleSurgical neurology international2025

A giant multinodular plexiform schwannoma of the brachial plexus: Differential diagnosis, multidisciplinary treatment, and surgical approach.

Carlo Mandelli, Cinzia Mura, Ervin Karaj, Andrea Bisoglio, Maria Rosa Terreni, Nazario Tenace, Pietro Mortini

Abstract readCase Reports
In one paragraph

Article in Surgical neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carlo MandelliDepartment of Neurosurgery, Ospedale San Raffaele, Milan, Italy.
Cinzia MuraDepartment of Neurosurgery, Ospedale San Raffaele, Milan, Italy.
Ervin KarajDepartment of Neurosurgery, Ospedale San Raffaele, Milan, Italy.
Andrea BisoglioDepartment of Neurosurgery, Ospedale San Raffaele, Milan, Italy.
Maria Rosa TerreniDepartment of Pathological Anatomy, Ospedale San Raffaele, Milan, Italy.
Nazario TenaceDepartment of Pathological Anatomy, Ospedale San Raffaele, Milan, Italy.
Pietro MortiniDepartment of Neurosurgery, Ospedale San Raffaele, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Plexiform schwannoma (PS) is a rare variant of schwannoma, characterized by multifascicular, intraneural, and multinodular growth. Its differential diagnosis from schwannomas, neurofibromas, and plexiform neurofibromas is essential for optimal treatment planning. Case Description: This article presents the case of a 53-year-old male who experienced stinging pain and weakness in his left hand, alongside muscle atrophy in the thenar eminence. Magnetic resonance imaging revealed a brachial plexus tumor, which was surgically resected. Histological analysis confirmed a brachial plexus schwannoma (the World Health Organization [WHO] grade I). After 3 years, the tumor recurred, leading to a two-stage surgical intervention. Histological examination identified it as a PS (the WHO grade I). Adjuvant tomotherapy achieved good long-term tumor control. Conclusion: This case highlights the difficulties in histopathological diagnosis and multidisciplinary management in achieving favorable outcomes, minimizing neurological risks.

Indexed as

Brachial plexusClinical outcomeGiant plexiform schwannomaMultinodular tumorSurgical outcome

Identifiers

PMID41216160
PMCPMC12596760

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