ArticleSurgical neurology international2025
Single-center retrospective analysis of responsive neurostimulation outcomes.
Article in Surgical neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
Background: Responsive neurostimulation (RNS) is a promising treatment for drug-resistant epilepsy (DRE). RNS has been shown to be safe and effective in reducing seizure frequency in patients with DRE. Methods: We performed a retrospective cohort study of patients with DRE implanted with the RNS system at our institution between 2017 and 2024. The patients had at least 6 months of clinical follow-up and two RNS programming sessions postimplantation. We collected data on patient demographics and postimplantation seizure frequency. Efficacy was assessed as the median percent change in postimplantation seizure frequency compared to baseline, as well as responder rate defined as >50% reduction in seizures. A one-way analysis of variance test was used to assess differences in mean postoperative seizure frequency across all lead placement groups, and Fisher's exact test was used to analyze differences in the proportion of patients achieving a postimplantation Engel classification of ≤2B. Results: Thirty patients were implanted with the RNS system at our institution between 2017 and 2024. Seventy-three percent of patients were male ( Conclusion: RNS system is a safe and effective treatment for DRE. The responder rate in our cohort is consistent with the seizure outcomes reported in the literature. Additional studies need to characterize the differences between RNS responders and nonresponders.
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