Evidence map›Paper›PMID 41216140›Full record

ArticleBrain communications2025

Cumulative incidence of motor and cognitive features in the amyotrophic lateral sclerosis-frontotemporal degeneration spectrum.

Barbara E Spencer, Sharon X Xie, Daniel T Ohm, Lauren Elman, Colin C Quinn, Defne A Amado, Michael Baer, Edward B Lee, Vivianna M Van Deerlin, Laynie Dratch and 3 more

Abstract read
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Barbara E SpencerDepartment of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID https://orcid.org/0000-0002-1685-2967
Sharon X XieDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Daniel T OhmDepartment of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID https://orcid.org/0000-0002-7930-5434
Lauren ElmanDepartment of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Colin C QuinnDepartment of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Defne A AmadoDepartment of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Michael BaerDepartment of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Edward B LeeDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID https://orcid.org/0000-0002-4589-1180
Vivianna M Van DeerlinDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Laynie DratchDepartment of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lauren MassimoDepartment of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
David J IrwinDepartment of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID https://orcid.org/0000-0002-5599-5098
Corey T McMillanDepartment of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Funding

Research Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVID A WOLK · 2021 to 2026
$24.8M
Understanding Environmental Contributions to Heterogeneity in bvFTD.P01AG066597 · NIA · UNIVERSITY OF PENNSYLVANIA · PI David John Irwin · 2020 to 2026
$18.8M
Microscopic and Large-Scale Networks of Molecular Pathology in Frontotemporal Lobar DegenerationR01NS109260 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI IRWIN, DAVID JOHN · 2019 to 2023
$3.8M
Shared and disparate genomic features of TDP-43 proteinopathiesF32AG079618 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SPENCER, BARBARA ELIZABETH · 2022 to 2024
$218k
NIA NIH HHS F32 AG079618NIA NIH HHS P01 AG066597NIA NIH HHS P30 AG072979NINDS NIH HHS R01 NS109260
6 · The paper itself

Abstract

In frontotemporal degeneration and amyotrophic lateral sclerosis, subsequent motor or cognitive-behavioural features, respectively, are associated with shorter survival. However, factors influencing subsequent feature development remain largely unexplored. In this study, we examined whether the presence of a

Indexed as

amyotrophic lateral sclerosisdementiaepidemiologyfrontotemporal degeneration

Identifiers

PMID41216140
PMCPMC12596572

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.