ArticleCureus2025
Posture-Induced Intraocular Pressure Changes After Ex-press Implantation Versus Medical Therapy in Primary Open-Angle and Normal-Tension Glaucoma: A Retrospective Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Posture-induced intraocular pressure (IOP) changes have been associated with glaucoma progression, and certain filtering surgeries reportedly suppress these changes. This study aimed to determine whether Ex-PRESS implantation also suppresses posture-induced IOP changes in glaucomatous eyes by comparing those treated with Ex-PRESS implantation and those under medical therapy. Methodology In this retrospective comparative chart review, 24 eyes after Ex-PRESS implantation without medications (EX group) and 31 eyes that underwent medical therapy (MED group) were analyzed. All eyes were diagnosed with primary open-angle glaucoma or normal-tension glaucoma with IOP measured by Goldmann applanation tonometry (IOPg) between 6 and 12 mmHg. Postural IOP change (ΔIOP) was defined as the difference between supine IOP (IOPisup) measured five minutes after assuming the supine position and sitting IOP (IOPisit), both measured using the iCare ic200. Results The IOPg results were comparable between groups (EX: 10.1 ± 1.7 mmHg; MED: 10.7 ± 1.2 mmHg; p = 0.2574). IOPisit was significantly lower in the EX group (EX: 9.1 ± 2.0 mmHg; MED: 10.4 ± 2.2 mmHg; p = 0.0117). IOPisup was also significantly lower in the EX group (EX: 10.2 ± 2.2 mmHg; MED: 13.7 ± 2.6 mmHg; p < 0.0001). Both groups had significant increases from IOPisit to IOPisup (EX: p = 0.0006; MED: p < 0.0001). ΔIOP was significantly smaller in the EX group (EX: 1.0 ± 1.3 mmHg; MED: 3.3 ± 2.2 mmHg; p < 0.0001). Conclusions Glaucomatous eyes treated with Ex-PRESS implantation had smaller posture-induced IOP changes than the medically treated eyes with similar IOP levels. These findings suggest that Ex-PRESS may offer additional benefits in stabilizing IOP variability beyond IOP reduction alone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.