ArticleAmerican heart journal plus : cardiology research and practice2025
Simultaneous carotid ultrasound and transcranial Doppler to detect cholesterol crystal emboli from unstable carotid plaque to the brain.
Article in American heart journal plus : cardiology research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Editorial for the Special Issue on Cholesterol Crystal Embolization.American heart journal plus : cardiology research and practice · 2026Article
- Cholesterol crystal formation and embolism in the central nervous system and their potential role in Alzheimer's disease.American heart journal plus : cardiology research and practice · 2026Article
- Cholesterol crystal embolization syndrome: Systemic and end-organ injury.American heart journal plus : cardiology research and practice · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Detection of unstable carotid plaques at risk for cholesterol crystal (CC) emboli to the brain causing strokes can be challenging. Although plaques with lumen stenosis of >70 % have been shown to pose a risk for embolism, detection prior to this stage of plaque progression (<70 % stenosis) may identify early instability. One such approach would be to obtain simultaneous carotid ultrasound (CUS) and transcranial Doppler (TCD) that can detect CCs discharged from plaque as a signal of instability. Application of contact pressure as usually applied by the interrogating ultrasound probe over a carotid artery during CUS that can trigger high intensity transient signals (HITS) on TCD could provide insight into plaque instability. To test this hypothesis, we evaluated 23 patients with moderate stenosis (∼50 %) by CUS/TCD to check for instability. Of the patients insonated, 4/21 had evidence of HITS on TCD during CUS and 3 had neurological symptoms. The presence of HITS was observed only for emboli from heterogenous/complex plaques (4/14) 28.6 % (95 % CI: 0.084-0.581),
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